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FGF1 — FGFBP1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: FGF1 → Complex of FGF1-FGFBP1 (directlyIncreases) Beer et al., Oncogene 2005*
  Evidence: The fibroblast growth factor-binding protein (FGF-BP) binds and activates FGF-1 and FGF-2, thereby contributing to tumor angiogenesis.

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: FGFBP1 — FGF1 (direct interaction, pull down) Tassi et al., J Biol Chem 2001*
• IRef Hprd Interaction: FGF1 — FGFBP1 (in vitro) Tassi et al., J Biol Chem 2001*
• IRef Ophid Interaction: FGF1 — FGFBP1 (aggregation, confirmational text mining) Tassi et al., J Biol Chem 2001*
• IRef Ophid Interaction: FGF1 — FGFBP1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Tassi et al., J Biol Chem 2001 : Furthermore, FGF-BP1 enhances FGF-1- and FGF-2 dependent proliferation of NIH-3T3 fibroblasts and FGF-2 induced extracellular signal regulated kinase 2 phosphorylation
Beer et al., Oncogene 2005 : The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity : implications for epithelial repair ... The fibroblast growth factor binding protein ( FGF-BP ) binds and activates FGF-1 and FGF-2, thereby contributing to tumor angiogenesis
Newman et al., Am J Physiol Lung Cell Mol Physiol 2007 : Functionally, FGF-BP shuttles FGFs from binding sites in ECMs to cell surfaces and enhances FGF binding and signaling, whereas NDST-1 adds sulfate groups to FGF coreceptor proteoglycans and modulates alveolar type II ( ATII ) cell maturation and differentiation
Wu et al., J Biol Chem 1991 : In addition HBp17 was found to inhibit the biological activities of both HBGF-1 and HBGF-2