Buteau et al., Diabetes 2003
(Prostatic Neoplasms) :
A time dependent increase in tyrosine phosphorylation of the EGFR in response to GLP-1 was observed in INS ( 832/13 ) cells
Miettinen et al., Biochem Soc Trans 2008
:
EGFR action is also necessary for the beta-cell mitogenic activity of the gut hormone GLP-1 ( glucagon-like peptide 1 )
Kimura et al., Neuroendocrinology 2013
(Brain Diseases, Metabolic...) :
Conclusion : The neuroprotective effects of GLP-1 against MG-induced apoptosis are mediated by EGFR transactivation, which signals through the PI3K/Akt/mTOR/GCLc/redox pathway in PC12 cells