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PI3 — TNF

Text-mined interactions from Literome

Pan et al., J Biol Chem 1999 (Adenocarcinoma...) : Tumor necrosis factor alpha (TNFalpha) also stimulated increased PI 3-kinase activity, however TNFalpha stimulated NF-kappaB activation was not affected by the PI 3-kinase inhibitors or the p85 dominant negative mutant
Hanna et al., J Biol Chem 1999 : Activation of PI 3-kinase by TNFalpha , sphingomyelinase, and C2-ceramide was inhibited by tyrosine kinase inhibitors ( genistein and PP1 )
Brindley et al., Lipids 1999 (Insulin Resistance) : The mechanisms by which TNF-alpha and ceramides increase PI 3-kinase activity were investigated further by using rat2 fibroblasts
Reddy et al., J Immunol 2000 : Consistent with its involvement in TNF signaling, PI 3-kinase activities in HepG2 and U937 cells can be stimulated by TNF in a rapid but transient manner through a mechanism that may involve its association with the insulin receptor substrate-1
Pfundt et al., Arch Dermatol Res 2000 : SB202190 or SB203580, two specific p38 MAP kinase inhibitors almost completely blocked the induction of SKALP expression by TNF-alpha and serum
Hiraoka et al., Am J Physiol Heart Circ Physiol 2001 : The activation of phosphatidylinositol (PI) 3-kinase and Akt/protein kinase B (PKB) by tumor necrosis factor (TNF)-alpha and their roles on stimulation of protein synthesis were investigated in cultured neonatal rat cardiac myocytes ... TNF-alpha induced marked activation of PI3-kinase and Akt/PKB, and the activation of PI3-kinase and Akt/PKB was rapid ( maximal at 10 and 15 min, respectively ) and concentration dependent ... Akt/PKB activation by TNF-alpha was inhibited by a PI3-kinase-specific inhibitor LY-294002 and adenovirus mediated expression of a dominant negative mutant of PI3-kinase , indicating that TNF-alpha activates Akt/PKB through PI3-kinase activation
Weaver et al., Gastroenterology 2001 : NF-kappaB binding activity was unaltered by PI 3-kinase inhibition in HT-29 cells, in which TNF-alpha was shown to activate PI 3-kinase directly ... TNF-alpha can activate PI 3-kinase directly in addition to inducing COX-2
Zhang et al., Cell Death Differ 2001 (MAP Kinase Signaling System) : These results suggest that TNF induced MAP kinase and PI3-kinase/Akt signaling play important roles in protecting BAE cells from TNF cytotoxicity
Beresford et al., J Interferon Cytokine Res 2001 (Prostatic Neoplasms) : Suppression of PI3'-kinase/Akt signaling markedly enhanced the apoptotic activity of both TNF and TRAIL in LNCaP cells but not in PC-3 cells
Kawanaka et al., Hepatology 2002 (Hypertension, Portal) : In PHT gastric mucosa we studied ( 1 ) eNOS phosphorylation ( at serine 1177 ) required for its activation ; ( 2 ) association of the phosphatidylinositol 3-kinase ( PI 3-kinase ), and its downstream effector Akt, with eNOS ; and, ( 3 ) whether TNF-alpha neutralization affects eNOS phosphorylation and PI 3-kinase-Akt activation
Kilpatrick et al., Am J Physiol Cell Physiol 2002 : In adherent neutrophils, TNF-alpha triggers association of both protein kinase C (PKC)-delta and phosphatidylinositol (PI) 3-kinase with the p60TNFR
Cadwallader et al., J Immunol 2002 : In contrast, both fMLP and TNF-alpha alone caused a 3-fold increase in PI3-kinase activity in p110gamma PI3-kinase immunoprecipitates
Pol et al., J Biomol Screen 2002 (Psoriasis) : Induction of the SKALP promoter by tumor necrosis factor-alpha resulted in increased expression levels of the secreted SKALP-EGFP fusion protein as assessed by direct readout of fluorescence and fluorescence polarization in 96-well cell culture plates
Pavalko et al., J Cell Physiol 2003 : FSS activated PI3-kinase signaling, induced phosphorylation of Akt, and inhibited TNF-alpha induced activation of caspase-3
Osawa et al., J Immunol 2003 : This proapoptotic action can be explained by its inhibitory findings on survival signals ; inhibition of TNF-alpha induced activation and expression of phosphatidylinositol 3-kinase (PI3K)/Akt , and also blockage of expression of Mcl-1, an antiapoptotic Bcl-2 family member which is located downstream of Akt, was inhibited by IEX-1S
Liu et al., Pediatr Res 2003 : These effects are mediated through both MEK and PI 3-kinase pathways but not through the IGF-I induction of TNF-alpha production by the DC
Kilpatrick et al., Am J Physiol Cell Physiol 2004 : Coimmunoprecipitation studies established that PI 3-kinase , delta-PKC, and TNFR-1 formed a signal complex in response to TNF ... These results suggest that delta-PKC and PI 3-kinase regulate TNF antiapoptotic signaling at the level of the TNFR-1 through control of assembly of a TNFR-1-TRADD-RIP-TRAF2 complex
Yoon et al., Rheumatol Int 2006 : Activation of p38 mitogen activated protein ( MAP ) kinase and phosphatidylinositol 3-kinase (PI3K) by TNF-alpha was inhibited with SB202190 and Ly 294002 respectively
Prasad et al., J Neurochem 2005 : It inhibits tumor necrosis factor alpha (TNFalpha) induced PI3-kinase , Akt and NF-kappaB activation in these cells
Nanua et al., Am J Respir Cell Mol Biol 2006 : Quercetin also inhibited TNF-alpha induced PI 3-kinase activity, Akt phosphorylation, intracellular H ( 2 ) O ( 2 ) production, NF-kappaB transactivation, IL-8 promoter activity, and steady-state mRNA levels, consistent with the notion that quercetin inhibits chemokine expression by attenuating NF-kappaB transactivation via a PI 3-kinase/Akt dependent pathway
Zeldich et al., J Cell Physiol 2007 : Although TNF induced the activation of p38 MAPK, JNK, ERK and PI-3K signaling, these pathways were not crucial for EMD protection of hGFs
Fakhrzadeh et al., Toxicol Appl Pharmacol 2008 (Pneumonia) : TNFalpha signaling involves PI-3-kinase (PI3K)/protein kinase B (PKB), and p44/42 MAP kinase (MAPK) which are important in NF-kappaB activation
Zhou et al., American journal of physiology. Renal physiology 2008 (Endotoxemia...) : TNF-alpha also caused PI3-kinase/Akt activation, which was further increased by PDTC and prevented by the PI3-kinase inhibitor, LY294002
Tseng et al., J Cell Physiol 2010 : TNF-alpha increased the FAK, PI3K , and Akt phosphorylation
Kim et al., Immune network 2011 : Both TNF-a and IL-6 production by HBHA was regulated by the NF-?B, PI3-K , and MAPK pathways
Fumagalli et al., J Immunol 2013 : Selective inhibitors of PI3Ka and PI3Kd markedly reduced both the early and late response to fMLF and TNF in human neutrophils
Guo et al., J Biol Chem 1996 : In murine 3T3-L1 adipocytes, IRS-1 and PI 3-kinase phosphorylation and the association of these proteins are promoted by murine TNF , which interacts with the type 1 and type 2 TNF receptors ... Human TNF , which binds to the murine type 1 TNF receptor selectively, also promotes IRS-1 phosphorylation and binding of IRS-1 to PI 3-kinase
Pelletier et al., Inflamm Res 1998 (Leukemia, Basophilic, Acute) : The PI 3-kinase inhibitor wortmannin blocked TNF-alpha secretion at low doses ( EC50= 13 nM ), but only partially affected mRNA expression ... Our results show that in FcepsilonRI stimulated RBL-2H3 cells calcium mobilization, activation of PKC and PI 3-kinase are necessary for TNF-alpha secretion while for the increased TNF-alpha mRNA expression PKC activity is dispensable and PI 3-kinase activity only partially required