Gene interactions and pathways from curated databases and text-mining

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EPO — NOS2

Text-mined interactions from Literome

Squadrito et al., Br J Pharmacol 1999 (Constriction, Pathologic...) : 3. Rh-EPO ( 25, 50 and 100 U 100 g ( -1 ), 5 min following the onset of reperfusion ) increased survival rate ( 70 % at 4 h of reperfusion with the highest dose ), reduced plasma nitrite/nitrate concentrations ( 10.3+/-3.3 microM ), increased MAP, did not change RBC count and blood Hb, and inhibited iNOS activity in thoracic aortae ... Finally rh-EPO inhibited the activity of iNOS in peritoneal macrophages activated with endotoxin
Genc et al., Physiol Res 2006 : The possible modulatory effect of erythropoietin on inducible nitric oxide synthase (iNOS) mRNA expression and nitrite production were also analyzed
Santhanam et al., Acta Pharmacol Sin 2006 (Vasospasm, Intracranial) : In this review, we discuss the EPO induced activation of endothelial nitric oxide ( NO ) synthase and its contribution to the prevention of cerebral vasospasm
Aoshiba et al., Crit Care Med 2009 (Disease Models, Animal...) : Erythropoietin also reduced inducible nitric oxide synthase expression, nitric oxide production, peroxynitrite formation, and tissue hypoxia
Mihov et al., Am J Physiol Cell Physiol 2009 : Erythropoietin activates nitric oxide synthase in murine erythrocytes
Zhang et al., J Clin Neurosci 2010 (Disease Models, Animal...) : The aims of this study were ( 1 ) to evaluate the effect of high-dose erythropoietin ( EPO ; 5000 U/kg ) on expression of inducible nitric oxide synthase (iNOS) in the facial nucleus after facial nerve transection ; and ( 2 ) to explore whether this effect is relevant to facial motor neuron survival
Contaldo et al., Shock 2011 : Erythropoietin requires endothelial nitric oxide synthase to counteract TNF-[alpha ] -induced microcirculatory dysfunction in murine striated muscle
Beleslin-Čokić et al., Cytokine 2011 (Anoxia) : However, iNOS increased at hypoxia and with EPO stimulation compared to normal oxygen tension
Su et al., J Cell Physiol 2012 : AMP activated protein kinase mediates erythropoietin induced activation of endothelial nitric oxide synthase
Oba et al., Int J Urol 2012 (Reperfusion Injury) : Erythropoietin significantly stimulated phosphorylation of Akt and endothelial nitric oxide synthase in the kidneys
Gui et al., International journal of ophthalmology 2011 : Effect of erythropoietin on the expression of HIF-1 and iNOS in retina in chronic ocular hypertension rats
Adelibieke et al., Circ J 2013 : Indoxyl sulfate suppressed EPO induced survival/proliferation, anti-apoptosis function, phosphorylation of endothelial nitric oxide synthase , and the expression of thrombospondin-1, an erythroid stimulating factor, in HUVECs
Coldewey et al., Kidney Int 2013 : In the kidneys of endotoxemic wild-type mice, EPO enhanced the phosphorylation of Akt, glycogen synthase kinase-3ß, and endothelial nitric oxide synthase , and inhibited the activation of nuclear factor-?B
López Ongil et al., Exp Nephrol 1996 : Recombinant human erythropoietin does not regulate the expression of endothelin-1 and constitutive nitric oxide synthase in vascular endothelial cells