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EPO — NOS2
Text-mined interactions from Literome
Squadrito et al., Br J Pharmacol 1999
(Constriction, Pathologic...) :
3.
Rh-EPO ( 25, 50 and 100 U 100 g ( -1 ), 5 min following the onset of reperfusion ) increased survival rate ( 70 % at 4 h of reperfusion with the highest dose ), reduced plasma nitrite/nitrate concentrations ( 10.3+/-3.3 microM ), increased MAP, did not change RBC count and blood Hb, and
inhibited iNOS activity in thoracic aortae ... Finally
rh-EPO inhibited the activity of
iNOS in peritoneal macrophages activated with endotoxin
Genc et al., Physiol Res 2006
:
The possible modulatory
effect of
erythropoietin on
inducible nitric oxide synthase (iNOS) mRNA expression and nitrite production were also analyzed
Santhanam et al., Acta Pharmacol Sin 2006
(Vasospasm, Intracranial) :
In this review, we discuss the
EPO induced activation of endothelial
nitric oxide ( NO ) synthase and its contribution to the prevention of cerebral vasospasm
Aoshiba et al., Crit Care Med 2009
(Disease Models, Animal...) :
Erythropoietin also
reduced inducible
nitric oxide synthase expression, nitric oxide production, peroxynitrite formation, and tissue hypoxia
Mihov et al., Am J Physiol Cell Physiol 2009
:
Erythropoietin activates
nitric oxide synthase in murine erythrocytes
Zhang et al., J Clin Neurosci 2010
(Disease Models, Animal...) :
The aims of this study were ( 1 ) to evaluate the
effect of high-dose
erythropoietin ( EPO ; 5000 U/kg ) on expression of
inducible nitric oxide synthase (iNOS) in the facial nucleus after facial nerve transection ; and ( 2 ) to explore whether this effect is relevant to facial motor neuron survival
Contaldo et al., Shock 2011
:
Erythropoietin requires endothelial
nitric oxide synthase to counteract TNF-[alpha ] -induced microcirculatory dysfunction in murine striated muscle
Beleslin-Čokić et al., Cytokine 2011
(Anoxia) :
However,
iNOS increased at hypoxia and with
EPO stimulation compared to normal oxygen tension
Su et al., J Cell Physiol 2012
:
AMP activated protein kinase mediates
erythropoietin induced activation of endothelial
nitric oxide synthase
Oba et al., Int J Urol 2012
(Reperfusion Injury) :
Erythropoietin significantly
stimulated phosphorylation of Akt and endothelial
nitric oxide synthase in the kidneys
Gui et al., International journal of ophthalmology 2011
:
Effect of
erythropoietin on the expression of HIF-1 and
iNOS in retina in chronic ocular hypertension rats
Adelibieke et al., Circ J 2013
:
Indoxyl sulfate suppressed
EPO induced survival/proliferation, anti-apoptosis function, phosphorylation of endothelial
nitric oxide synthase , and the expression of thrombospondin-1, an erythroid stimulating factor, in HUVECs
Coldewey et al., Kidney Int 2013
:
In the kidneys of endotoxemic wild-type mice,
EPO enhanced the phosphorylation of Akt, glycogen synthase kinase-3ß, and endothelial
nitric oxide synthase , and inhibited the activation of nuclear factor-?B
López Ongil et al., Exp Nephrol 1996
:
Recombinant human
erythropoietin does not
regulate the expression of endothelin-1 and constitutive
nitric oxide synthase in vascular endothelial cells