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EGF — SOAT1
Text-mined interactions from Literome
Olayioye et al., J Biol Chem 1999
:
However, dominant negative Jaks did not affect
EGF induced
Stat phosphorylation
Kawamata et al., Int J Oncol 1999
(Urinary Bladder Neoplasms) :
Reportedly
EGF activates
STAT , induces the expression of p21waf1, and subsequently inhibits the growth of several types of cancer cells
Rebsamen et al., J Mol Cell Cardiol 2000
(Cardiomegaly) :
We also investigated
EGF induced activation of
Stat ( signal transducers and activators of transcription ) proteins as well as the possible interactions of this signaling pathway with the p38 and p42/44 MAP kinases cascades
Garcia et al., Oncogene 2001
(Breast Neoplasms) :
While EGF-R kinase activity is not required for constitutive Stat3 activation in breast cancer cells,
EGF stimulation further
increases STAT DNA binding activity, consistent with an important role for EGF-R in STAT signaling and malignant progression
Berclaz et al., Int J Oncol 2001
(Adenocarcinoma, Mucinous...) :
Both these events lead to activation of
STAT proteins, Src kinases activate STAT3 dependent transcription in mammary epithelial cells and
EGF receptor activation can
lead to activation of STATs 1 and 3
Burova et al., Tsitologiia 2001
:
Herein, we postulate that
EGF receptor
plays a role in H2O2 induced
STAT activation in HER14 cells
Zhang et al., Biochem J 2003
:
Since Ras-MAPK and
STAT pathways are simultaneously
stimulated by
EGF , and Tyr-1086 and Tyr-1068 of EGFR are reported to be the binding sites for both Grb2 and Stat3, we investigated the possible regulatory role of Grb2 in STAT activation
Burova et al., Tsitologiia 2003
:
[STAT1 and STAT3 activation by oxidative stress in A431 cells
involves Src dependent
EGF receptor transactivation ]
Gonchar et al., Tsitologiia 2003
:
The inhibition of ROS generation by DPI declined
EGF dependent activation of EGF receptor and
STAT factors to basal level ... Our results demonstrate the essential role of cellular red-ox status in the modulation of
EGF mediated activation of receptor and
STAT factors
Leaman et al., Mol Cell Biol 1996
:
In cells transfected with a kinase negative mutant EGF receptor, there is no
STAT activation in
response to
EGF and c-fos is not induced, showing that the kinase activity of the receptor is required, directly or indirectly, for these two responses
Chin et al., Mol Cell Biol 1997
:
We further demonstrated that both
EGF and IFN-gamma induced caspase 1 ( interleukin-1beta converting enzyme [ ICE ] ) gene expression in a
STAT dependent manner
Iwamoto et al., J Biol Chem 1998
:
Using a reconstituted in vitro STAT activation system, we have identified and partially purified a potential inhibitor ( s ) that is membrane associated and can block
STAT activation
induced by
EGF in vitro