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IGF1 — STAT5A

Text-mined interactions from Literome

Zong et al., J Biol Chem 2000 : We found that STAT3, but not STAT5 , was activated in response to IGF-I in 293T cells cotransfected with IGF-IR and STAT expression vectors
Davey et al., Endocrinology 2001 : Thus, STAT5b plays an important and specific role in liver Igf-I gene expression
Tronche et al., Genes Dev 2004 : We show that Stat5 proteins physically interact with GR and GR is present in vivo on Stat5 dependent IGF-I and ALS regulatory regions
Wang et al., J Biol Chem 2005 : These results together suggest that this STAT5 binding site containing distal 5'-flanking region of IGF-I gene may be an enhancer mediating GH-induced STAT5 activation of IGF-I gene transcription
Ahmed et al., Am J Physiol Gastrointest Liver Physiol 2006 : Growth hormone (GH) stimulates STAT5 phosphorylation by JAK2, which activates IGF-I and serine protease inhibitor 2.1 ( Spi 2.1 ) transcription, whereas STAT5 dephosphorylation by protein tyrosine phosphatases (PTPs) terminates this signal
Fleenor et al., Horm Res 2006 : Growth hormone and prolactin receptors in adipogenesis : STAT-5 activation, suppressors of cytokine signaling, and regulation of insulin-like growth factor I
Klover et al., Endocrinology 2007 : These results demonstrate an as yet unreported critical role for STAT5 in skeletal muscle for local IGF-I production and postnatal growth and suggest the skeletal muscle as a major site of GH action
Haffner et al., BMC cancer 2007 (Breast Neoplasms...) : The STAT5 induced IGF-I acts as an endocrine and para/autocrine growth and differentiation factor in mammary gland development
Eleswarapu et al., Endocrinology 2008 : Here we report the identification of three additional chromosomal regions containing a total of five putative STAT5 binding sites that may mediate GH-induced STAT5 activation of IGF-I gene expression in the mouse liver ... Overall, these results suggest that GH-induced STAT5 activation of IGF-I gene expression in the mouse liver might be collectively mediated by at least eight STAT5 binding sites located in distal intronic and 5'-flanking regions of the IGF-I gene
Nielsen et al., J Clin Endocrinol Metab 2008 : The GH bolus as well as GH infusion induced phosphorylation of Stat5 in muscle and fat, and SOCS3 and IGF-I mRNA expression increased after GH infusion
Li et al., J Endocrinol 2010 (Hyperglycemia...) : NO-1886 suppresses diet induced insulin resistance and cholesterol accumulation through STAT5 dependent upregulation of IGF1 and CYP7A1
D'Mello et al., Inflamm Bowel Dis 2012 (Body Weight...) : Hepatic GHR abundance, GH induction of Stat5 tyrosine phosphorylation, and Igf-I mRNA expression were reduced in male card15-deficient mice with ileitis due to GM-CSF neutralization and NSAID exposure
Zhang et al., Lipids in health and disease 2013 : Effects of insulin and IGF-I on growth hormone- induced STAT5 activation in 3T3-F442A adipocytes ... These results indicate that both insulin and IGF-I specifically potentiated GH mediated STAT5 activation in mature adipose cells