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LAT — NGF

Text-mined interactions from Literome

Frazier et al., J Virol 1996 : To identify pathways leading to LAT activation in vitro, we characterized the response of the LAT promoter to NGF and/or NaB in PC12 derived cell lines containing mutations in specific signal transduction pathways ... Together, these results indicate that the LAT promoter is regulated via the Ras/Raf signal transduction pathway in response to external factors such as NGF and NaB and that LAT expression may be regulated by NGF in latently infected neurons
Frazier et al., J Virol 1996 : Consistent with this hypothesis, we have recently demonstrated that LAT expression is significantly enhanced by nerve growth factor (NGF) and sodium butyrate ( NaB ) in neurally derived PC12 cells ... In contrast to basal expression, maximum induction of the LAT promoter by NGF and NaB requires sequences between -159 and -81 ... These regions were critical for complex formation in vitro and for maximum induction of the LAT promoter by NGF and NaB in transient expression assays