Jaksits et al., J Immunol 2004
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We conclude that Cdc42 and Rac1 signaling controls DC morphology and conditions DCs for efficient CD8 ( + ) T cell stimulation
Harada et al., Blood 2012
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However, Cdc42 activation at the leading edge membrane was impaired in DOCK8-deficient DCs , resulting in a severe defect in amoeboid polarization and migration