Gene interactions and pathways from curated databases and text-mining

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BTK — GP6

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Atkinson et al., Blood 2003 : These results demonstrate an essential requirement for Tec and Btk in platelet activation by GPVI and reveal a functional role for Tec in the regulation of PLC gamma 2 in the absence of Btk
Hsu et al., Immunol Lett 2013 (Arthritis, Rheumatoid...) : A potent and selective BTK inhibitor, RN486, inhibited GPVI- or CLEC2 mediated PLC?2 phosphorylation and pMP production in a dose dependent manner