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CDK2 — TNF

Text-mined interactions from Literome

Gaiotti et al., Mol Carcinog 2000 : Tumor necrosis factor-alpha promotes human papillomavirus ( HPV ) E6/E7 RNA expression and cyclin dependent kinase activity in HPV immortalized keratinocytes by a ras dependent pathway
Moneo et al., J Cell Biochem 2003 : We show that TNF induces p21 ( waf1 ) protein in malignant melanoma A375 cells and its binding to CDK2/4 and 6 proteins, and thereby inhibiting the activity of these complexes
Lee et al., Immunopharmacol Immunotoxicol 2012 : TNF-a induced the expression of CDK2/CDK4 , and reduced the expression of p21 ( waf1/cip1 ) /p27 ( kip1 )
Tsuji et al., Exp Cell Res 1993 : We observed that TNF induced CDC2 and CDK2 expression in early-passage quiescent WI-38 fibroblasts ... However, as cells approached senescence, their ability to induce CDC2 and CDK2 , as well as stimulate DNA synthesis in response to TNF , progressively declined, with minimal to absent induction in senescent cells ... These results demonstrate that senescent cells are selectively deficient in TNF mediated induction of CDC2 and CDK2 , genes crucial to DNA synthesis and mitosis