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DEFB4B — TNF

Text-mined interactions from Literome

Nitschke et al., Exp Nephrol 2002 : Coincubation of the cultured cells with IL-1alpha or E. coli promote the strongest hbd-2 induction whereas TNF-alpha and LPS lead to a weaker or no ( IL-6 ) hbd-2 induction
Tsutsumi-Ishii et al., J Immunol 2003 : Furthermore, IL-1beta and TNF-alpha in the culture supernatants from LPS stimulated monocytic cells activated the hBD-2 promoter in A549 cells ... In addition, a mutation of the NF-kappaB site at -200 ( pkappaB1 site ) completely abolished this IL-1beta- and TNF-alpha induced hBD-2 promoter activation, whereas NF-kappaB inhibitors ( MG-132 and helenalin ) strongly suppressed it
McDermott et al., Invest Ophthalmol Vis Sci 2003 : IL-1beta and TNFalpha each stimulated the expression of hBD-2 in HCECs and were more effective in combination than alone
Vankeerberghen et al., J Periodontol 2005 (Periodontal Pocket) : In addition to the published observations ( PMA induces hBD-2 and -4 ; TNF-alpha induces hBD-2 and -3 ), it was found that PMA can upregulate hBD-1 and hBD-3, whereas TNF-alpha can induce hBD-4
Kanda et al., Am J Physiol Cell Physiol 2007 : Antisense oligonucleotides against NF-kappaB components p50 and p65, AP-1 components c-Jun and c-Fos, or H1 antagonist pyrilamine suppressed hBD-2 production induced by histamine plus TNF-alpha or IFN-gamma
Kim et al., J Endod 2010 (MAP Kinase Signaling System) : TNF-alpha and IL-1 alpha synergistically increased hBD-2 messenger RNA levels, protein expression, and activity
Wolgin et al., Arch Oral Biol 2012 : Pretreatment with nicotine caused a significant 2.5-fold inhibition of TNF-a stimulated hBD-2 mRNA expression compared to TNF-a alone ( p = 0.004 )
Hau et al., Am J Pathol 2013 (Psoriasis) : siRNAs targeting NF-?B p65 and STAT3 suppressed visfatin plus TNF-a induced hBD-2 and S100A7 production