Gene interactions and pathways from curated databases and text-mining

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IRF3 — TNF

Text-mined interactions from Literome

Bennett et al., Blood 2006 (Inflammation...) : Thus, knock-down of RAX expression by 80 % using small interfering RNA ( siRNA ) prevents IFNgamma/tumor necrosis factor alpha (TNFalpha) induced PKR activation and eIF2alpha phosphorylation, IkappaB degradation, IRF-1 expression, and STAT1 phosphorylation, resulting in enhanced murine embryonic fibroblast (MEF) cell survival
Sweeney et al., Arthritis Rheum 2007 (Arthritis, Rheumatoid) : Poly ( I-C ), lipopolysaccharide, and tumor necrosis factor alpha (TNFalpha) activated phosphorylation of IKKepsilon and IRF-3 in FLS
Paun et al., J Biol Chem 2008 (Newcastle Disease) : In addition, IRF-5 regulates TNFalpha but not type I interferon gene transcription in Newcastle disease virus infected peritoneal macrophages
Wu et al., Hepatology 2009 : TLR stimulated expression of proinflammatory cytokines [ tumor necrosis factor alpha (TNF-alpha) , interleukin-6 (IL-6) ], and activation of IRF-3 was suppressed after up-regulation of HBV replication in HBV-Met cells