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RAC2 — TNF

Text-mined interactions from Literome

Nosaka et al., Biochem Biophys Res Commun 2001 (Fibrosarcoma) : Using the Rac binding domain of PAK ( PAK-RBD ) as an activation-specific probe, here we demonstrate that TNFalpha very rapidly and transiently activates the Rho family GTPase Rac in L929 cells ... The PI3K inhibitor LY294002 significantly inhibited TNFalpha activation of Rac as well as Erk and abolished that of the PI3K target Akt, without showing any inhibitory effects on JNK and p38 activation
Shyu et al., J Biomed Sci 2009 : TNF-alpha induced phosphorylation of Rac, while atorvastatin and Rac-1 inhibitor inhibited the phosphorylation of Rac induced by TNF-alpha
Balasubramanian et al., J Biol Chem 2011 : In addition, TNF-a activation of NF-?B in NIH 3T3 cells is dependent on Rac activation, as evidenced by the inhibition of TNF-a induction of NF-?B mediated transcription by a dominant inhibitory form of Rac1 ... A role for Rac in the inhibitory action of mGBP-2 on NF-?B is further shown by the findings that mGBP-2 inhibits TNF-a activation of endogenous Rac and constitutively activate Rac can restore NF-?B transcription in the presence of mGBP-2
Naikawadi et al., Circ Res 2012 : TNF-a stimulated Rac activation and reactive oxygen species production in a P-Rex1 dependent manner
Waheed et al., Mol Biol Cell 2013 : Central role of the exchange factor GEF-H1 in TNF-a induced sequential activation of Rac , ADAM17/TACE, and RhoA in tubular epithelial cells ... Taken together, our findings can explain the mechanisms leading to hierarchical activation of Rac and RhoA by TNF-a through a single GEF
Spencer et al., Am J Physiol Gastrointest Liver Physiol 2013 (Reperfusion Injury) : Cumulatively, these results demonstrate that NOX2 and its activator subunits ( p47(phox) and Rac ) control the secretion of TNF-a by the liver following I/R. Interestingly, in the absence of Kupffer cells and NOX2, NOX1 played a dominant role in TNF-a production following hepatic I/R