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RAD21 — TP53

Text-mined interactions from Literome

Tang et al., J Biol Chem 2002 : In response to DNA damage, ataxia-telangiectasia mutant and ataxia-telangiectasia and Rad-3 activate p53 , resulting in either cell cycle arrest or apoptosis
Liu et al., Anticancer Res 2011 (Breast Neoplasms) : The p53 pathway was involved in the synergism of RAD001 and carboplatin on breast cancer cell proliferation and apoptosis, since the synergistic effect was demonstrated in all tested breast cancer cell lines with wild-type p53 and the use of p53 inhibitor partially antagonized the effect of RAD001 and carboplatin on p53 and p21 expression, as well as their inhibitory effect on cell proliferation
Ghosh et al., J Radiat Res 2012 (Neutropenia...) : The results demonstrated that Ex-RAD ameliorates radiation induced peripheral blood cell depletion, promotes bone marrow recovery, reduces p53 signaling in spleen and protects intestine from radiation injury