Gene interactions and pathways from curated databases and text-mining

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CD40LG — JUN

Text-mined interactions from Literome

Shen et al., J Immunol 2001 : We demonstrate that AP-1 ( Fos and Jun ), induced transiently by CD40 ligand or LPS, binds a DNA element in the mouse GL epsilon promoter
Dupoux et al., Blood 2009 : This degradation is required for the macrophages to be fully functional as TRAF2 overexpression in differentiated cells decreases the c-Jun N-terminal kinase mediated synthesis and the secretion of proinflammatory cytokines, such as interleukin-8 and monocyte chemoattractant protein 1 ( MCP-1 ) in response to CD40 ligand
Zhao et al., Invest Ophthalmol Vis Sci 2010 (Graves Ophthalmopathy...) : CD40L induced the phosphorylation of p38 MAPK, extracellular regulated kinase1/2 ( ERK1/2 ), c-Jun NH2-terminal kinase (JNK) , and IkappaB and the activation of NF-kappaB
Rau et al., Hepatology 2013 (Hepatitis C...) : The antiviral effect of CD40L required activation of c-Jun N terminal kinases (JNK)1/2 , but not induction of apoptosis or the JAK/STAT pathway that is necessary for the antiviral effects of IFNs
Brenner et al., FEBS Lett 1997 : Activation of T-lymphocytes via gp39/CD40L induced a strong activation of Jun-N-terminal kinase (JNK) and p38-K