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CD2 — IL2

Text-mined interactions from Literome

Martelli et al., Blood 2000 : As predicted, the absence of either LAT or ZAP70/Syk kinases correlated with a defect in the induction of nuclear factor of activated T cells ( NFAT ) transcriptional activity, activation of the interleukin-2 promoter, and ERK phosphorylation following CD2 stimulation
Marti et al., J Immunol 2001 : A similar enhancement of IL-2 secretion is observed neither in response to TCR plus CD2 costimulatory receptor engagement nor in response to other mitogenic stimuli such as phorbol ester and ionomycin
Némorin et al., J Immunol 2001 (Calcium Signaling) : However, both CD3- and CD2 induced NF-AT activation and IL-2 secretion are impaired in p62(dok) overexpressing cells
Pipitone et al., Eur J Immunol 2001 : Furthermore, we also demonstrated that IL-2 , IL-7 and IL-15 could induce de novo the synthesis of LFA-1 and CD2
Thornton et al., Pediatr Res 2003 : Likewise, anti-CD2/CD3/CD28 stimulated IL-2 production by the neonate was lower than adult levels but did not differ with mode of delivery
Musgrave et al., J Interferon Cytokine Res 2003 : Induction of nonspecific CTL and interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) synthesis were impaired in the absence of CD2-CD48 interactions ... We conclude that CD2-CD48 interactions during T cell activation are critical for the synthesis of sufficient IL-2 and IFN-gamma to drive CD8 ( + ) T cells to differentiate into functional cytotoxic effector cells
Butler et al., J Cell Biochem 2003 : Collectively, these data suggest that CD2 and CD28 up-regulation following T cell activation is IL-2 dependent ; and that adenosine inhibits activation induced T cell expression of CD2 and CD28 by interfering with IL-2 dependent signaling
Lorré et al., Eur Cytokine Netw 1992 : We conclude that CD3 or CD2 triggering are not sufficient for TNF-alpha production by T cells, but that the latter is dependent ( apparently at the transcriptional level ) on the interaction of IL-2 with its functionally active cell surface receptors
Cerdan et al., J Immunol 1992 : Whereas activation through CD2 or CD28 alone induced no or only low IL-2R alpha chain expression, activation through CD2 plus CD28 led to both a high and prolonged ( greater than 14 days ) cell surface and mRNA expression
Song et al., Aging (Milano) 1992 : Anti-CD2 stimulation resulted in equal IL-2 synthesis by cells from young and old donors that was comparable to the amount produced by cells from elderly donors stimulated with immobilized anti-CD3
Musgrave et al., Cell Immunol 2004 : CD2-CD48 interactions promote interleukin-2 and interferon-gamma synthesis by stabilizing cytokine mRNA
Koretzky et al., Proc Natl Acad Sci U S A 1991 : Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2 mediated activation of a protein tyrosine kinase and interleukin 2 production
Makni et al., J Immunol 1991 (Leukemia, Biphenotypic, Acute) : Reconstitution of CD2 expression by gene transfer in two J32 CD2- mutants restored IL-2 production and IL-2 mRNA accumulation in responses to both anti-CD2 and anti-CD3-TCR mAb
Chang et al., J Exp Med 1990 : Stimulation of transfectants CD2 FL, CD2 M1 ( 271-272 ), and CD2 M2 ( 278-279 ) with anti-T11 ( 2 ) + anti-T11 ( 3 ) antibodies resulted in a rise in cytosolic-free calcium [ ( Ca2+ ] i ) and subsequent interleukin 2 (IL-2) secretion
Cheadle et al., Gene Ther 2012 : Moreover, the high levels of IL-2 produced by human T cells engrafted with a second-generation CD28 containing CAR during target-cell recognition are dependent to a degree upon CD2 receptor activity
Burdach et al., Blood 1988 : Next we assessed the effect of CD2 blockade on IL-2
Bierer et al., J Exp Med 1988 : Expression of the CD2 molecule markedly enhances IL-2 production in response to LFA-3+ antigen bearing stimulator cells, and this stimulation is inhibited by anti-CD2 and anti-LFA-3 mAb
Kotlán et al., Immunol Lett 1988 : The different effect of alpha and gamma interferons and interleukin 2 on the expression of CD2 , CD3, CD4 and CD8 antigens in comparison to histocompatibility antigens of human lymphocytes ... IL-2 affected the expression of CD2 and CD8 antigens only marginally, but did not affect that of CD3 and Leu-7 ; however, it strongly enhanced the expression of HLA-ABC, HLA-DR, and beta 2m antigens
Trifiletti et al., Cell Immunol 1989 : Since in other experimental systems the activation of T cells by CD2/LFA-3 interactions has resulted in increased secretion of interleukin 2 (IL2) , we were interested in studying the role of IL2 in PBMC cultures stimulated with PWM and autologous E
Dalloul et al., Eur J Immunol 1989 : Anti-CD2 and PHA, but not IL 2, induced intracytoplasmic Ca2+ influx phosphatidyl inositol turnover as well as IL 2 receptor expression
Eldridge et al., J Immunol 1985 (Leukemia P388) : In addition, the IL 2 plus B15 sup supported anti-SRBC PFC response was increased by the addition of an interleukin 1-containing fraction from the supernatant of the macrophage line P388D1
Ocklind et al., Scand J Immunol 1988 : Inhibition studies with MoAb suggest that ( 1 ) concurrent stimulation of CD3 and CD2 is essential for interleukin 2 production and proliferation, since SE-UCHT1 treated with the anti-T11TS MoAb L180/1 are not mitogenic ; ( 2 ) proximity of CD3 and CD2 is required during the stimulation, since a mixture of SE exposing either anti-CD3 or T11TS is not mitogenic ; and ( 3 ) that T cell-AC interactions involving LFA-1 can be replaced by LFA-3-CD2 interactions, since the anti-LFA-1 MoAb 60.3 does not inhibit the SE-UCHT1 response, and only partly the SE + PHA response
Halvorsen et al., Scand J Immunol 1988 : IL-2 receptors were induced after activation via CD2 or CD3 alone, while IL-2 production in both CD4+ and CD8+ T cells required activation via both CD3 and CD2
Burdach et al., Behring Inst Mitt 1988 : Hematopoietic effects of IL-2 are mediated by CD2/LFA-3 receptor ligand interactions
Yang et al., J Immunol 1988 : It is demonstrated that high affinity IL-2R can be readily induced by either anti-CD3 and/or anti-CD2 stimulation
Mentz et al., Blood 1994 (Leukemia-Lymphoma, Adult T-Cell) : Analysis of intracellular signals transduced during T-ALL differentiation indicated that CD2-ligation induced Ca2+ influx and that the ligation of CD2 and IL-2R induced distinct tyrosine phosphorylation patterns
Hahn et al., J Immunol 1993 : In murine T cell hybridomas transfected with human CD2, we show that, unlike CD2 mediated IL-2 production, cell surface expression of the TCR-CD3 structure is not required for up-regulation of CD2 ligand avidity
Kimata et al., J Virol 1993 : Induction of interleukin-2 expression was inhibited by anti-CD2 and anti-lymphocyte function associated antigen 3 ( LFA-3 ) monoclonal antibodies but not anti-human leukocyte antigen-DR, anti-CD4, anti-LFA-1, or anti-intercellular adhesion molecule 1
Kishiro et al., Jpn J Pharmacol 1994 : Interleukin (IL)-2 secreted from splenocytes in response to SRBC was increased by adding butyrate to the culture, but IL-1 secretion was not affected
Cerwenka et al., J Immunol 1994 : However, cells activated in the presence of TGF-beta 1 proliferated vigorously in secondary cultures and produced highly elevated amounts of IL-2 ( 12 +/- 3-fold enhancement of IL-2 production in response to CD2 plus CD28 stimulation compared with control cells, mean +/- SEM ; n = 10 )
Costello et al., Eur J Immunol 1993 : Blocking antibodies confirmed the crucial role of IL-2 in CD2 + CD28 activation
Chavin et al., Ann Surg 1993 : Combination anti-CD2 and anti-CD3 monoclonal antibodies induce tolerance while altering interleukin-2, interleukin-4 , tumor necrosis factor, and transforming growth factor-beta production
Mäenpää et al., Int J Cancer 1993 : CD2 , CD44, CD54 and CD58 were increased by IL-2 but L-selectin was strongly down-regulated on the long-term activated NK cells
Lin et al., Pathobiology 1995 : Increased cAMP and cAMP dependent protein kinase activity mediate anti-CD2 induced suppression of anti-CD3-driven interleukin-2 production and CD25 expression ... Since interleukin(IL)-2 production and IL-2 receptor ( IL-2R ; CD25 ) expression are important determinants of CD3-driven T cell activation, the effects of anti-CD2 on anti-CD3 induced CD25 expression and IL-2 production were analyzed and related mechanistically to CD2 stimulated cAMP signaling with an in vitro model of T cell activation
Hubert et al., J Immunol 1996 : By contrast, CD2 induces PLCgamma-1 tyrosine phosphorylation as efficiently as CD3, with a correlated inositol phosphate production and intracellular calcium increase, and even a higher production of IL-2
Tanaka et al., Eur J Immunol 1997 : Itk, a T cell-specific tyrosine kinase, is required for CD2 mediated interleukin-2 promoter activation in the human T cell line Jurkat
Itescu et al., Hum Immunol 1998 : IL-2 augmented NK lysis involved interactions between CD2 and CD49d on baboon NK cells and their respective ligands on porcine endothelium, since NK lysis was reduced either by using Mabs against CD2, CD49d, or porcine VCAM, or by treating endothelial cells with PIPLC to cleave GPI linked molecules
King et al., Int Immunol 1998 (Leukemia, T-Cell) : Furthermore, we show that, unlike wild-type rat CD2, PR4 deleted rat CD2 is unable to induce IL-2 secretion from Jurkat cells
Kivens et al., Mol Cell Biol 1998 : Mutations in the CD2 cytoplasmic domain implicated in CD2 mediated interleukin-2 production or CD2 avidity do not affect CD2 regulation of integrin activity
Sunder-Plassmann et al., J Biol Chem 1998 : CD2 mediated interleukin-2 production occurs via activation of Jun kinase in cell lines lacking p56