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CD40LG — NFKB1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Warren et al., Mol Immunol 1999
:
EMSA with crude nuclear extracts demonstrated that stimulation with
CD40L results in the induction of
NF-kappaB complexes that bind to each of the three NF-kappaB sites and are composed mainly of p50 and RelB, but also include c-Rel and p65
Woltman et al., J Am Soc Nephrol 2000
:
Stimulation of TEC with
CD40L results in activation of
NF-kappaB and induction of cytokine production by IL-17 and CD40L is prevented by addition of the NF-kappaB inhibitor pyrrolidine dithiocarbamate
Tone et al., Proc Natl Acad Sci U S A 2001
:
The interaction between CD40 and
CD40 ligand ( CD154 )
activates NF-kappa B , Jun N-terminal kinase, and Janus kinase/signal transducers and activators of transcription pathways and promotes B cell growth, differentiation, and survival as well as IL-12 production in macrophages and dendritic cells
Du et al., J Neuroimmunol 2001
(Encephalomyelitis, Autoimmune, Experimental) :
Our data also show that tyrphostin A1 blocks
CD40L induced translocation of
NF-kappaB to the nucleus, and reduces the activation of IL-12 p40 gene
Srahna et al., Clin Exp Immunol 2001
:
NF-kappaB is
involved in the regulation of
CD154 ( CD40 ligand ) expression in primary human T cells
Qian et al., Proc Natl Acad Sci U S A 2002
:
Furthermore, transfection of Act1 into C33A cervical epithelial cells, which do not express it, renders these cells sensitive to
CD40 ligand induced
NF kappa B activation and protects them from CD40 ligand induced apoptosis
Kiriakidis et al., J Cell Sci 2003
(Inflammation...) :
Because LPS and
CD40L activate
nuclear factor-kappaB (NF-kappaB) in monocytes, we investigated in this study whether VEGF production in macrophages, when stimulated with either LPS or CD40L, is NF-kappaB dependent
Liu et al., J Biol Chem 2003
:
TRAP expression in osteoclasts is
regulated by receptor activator of
NF-kappaB ( RANKL ), a potent activator of osteoclast differentiation
Méndez-Samperio et al., Clin Diagn Lab Immunol 2003
:
NF-kappaB is
involved in regulation of
CD40 ligand expression on Mycobacterium bovis bacillus Calmette-Guérin activated human T cells ... These data strongly suggest that
CD40L expression by BCG activated CD4 ( + ) T cells is
regulated via the PKC pathway and by
NF-kappaB DNA binding activity
Fotin-Mleczek et al., J Biol Chem 2004
:
Moreover, down-regulation of TRAF1 with small interfering RNAs enhanced
CD40/CD40 ligand induced
NF-kappaB activation but showed no effect on TNF signaling
Zhang et al., Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2004
(Burkitt Lymphoma) :
[ BAY11-7082 and Lactacystein in
CD154 induced
NF-kappaB activation ] ... To investigate the inhibition mechanisms of BAY11-7082 ( IkappaB-alpha phosphorylation inhibitor ) and Lactacystein ( proteosome inhibitor ) in
CD154 induced
NF-kappaB activation ... We used recombinant CD154 to stimulate EBV/LMP1 negative Ramos B cell and observed the effects of BAY11-7082 and Lactacystein in
CD154 induced
NF-kappaB luciferase
activation , phosphorylation and degradation of IkappaB-alpha, phosphorylation of p65, and nuclear translocation of NF-kappaB subunits upon CD154 stimulation ... Both BAY11-7082 and Lactacystein abrogated
CD154 induced
NF-kappaB luciferase activation in Ramos cells ... BAY11-7082 and Lactacystein inhibit
CD154 induced
NF-kappaB activation through different mechanisms
Vakkila et al., J Immunol Methods 2004
:
NF-kappaB responses to IL-1beta,
CD40L , and LPS were donor dependent ( n=7 ), correlated with the quality of iDC preparations ( p=0.002 ), and IL-12 p70 production ( p=0.010 )
Severa et al., Biochem Pharmacol 2005
:
A marked reduction of
NF-kappa B binding to the kappa B sequences present within the p35 and p40 subunit promoters was
observed in diltiazem treated DCs following the stimulation with lipopolysaccharide (LPS) or
CD40L
Tai et al., Cancer Res 2005
(Multiple Myeloma) :
Immunoblotting analysis specifically showed that PI3-K/AKT,
nuclear factor-kappaB (NF-kappaB) , and extracellular signal regulated kinase activation
induced by
CD40L ( 5 mug/mL ) was inhibited by CHIR-12.12 ( 5 mug/mL )
Pontrelli et al., J Am Soc Nephrol 2006
:
Lyn inhibition did not have any effect on
CD40L induced
NF-kappaB activation and MCP-1 expression but abolished PAI-1 induction
Ye et al., Mol Cell Biol 2008
:
These motifs are also required for Monarch-1 to undergo self-oligomerization, Toll-like receptor- or
CD40L activated association with
NF-kappaB inducing kinase (NIK) and interleukin-1 receptor associated kinase 1 ( IRAK-1 ), degradation of NIK, and inhibition of IRAK-1 phosphorylation
Vakkila et al., Scand J Immunol 2008
:
By contrast, PGE2 supplemented DC could be characterized by negligible responses to LPS and IFN-gamma and a remarkable
NF-kappaB response to
CD40L
Wang et al., Leukemia & lymphoma 2008
(Burkitt Lymphoma) :
CD40L mediated inhibition of
NF-kappaB in CA46 Burkitt lymphoma cells promotes apoptosis
Zhu et al., Transplant Proc 2008
:
We undertook this study to determine whether
CD154-CD40 interactions induced human endothelial cell ( EC ) activation via the nuclear factor (NF)-kappaB pathway, and whether the upregulation of monocyte derived CD40 and CD80 is
NF-kappaB pathway
dependent
Song et al., PloS one 2011
(Carotid Artery Injuries...) :
In vitro data revealed that CD40 deficiency blocked
CD40L induced
NF-kB p65 nuclear translocation in leukocytes
Vakkila et al., Drug Discov Today 2005
:
NF-kappaB responses to IL-1beta,
CD40L , and LPS were donor dependent ( n = 7 ), correlated with the quality of iDC preparations ( p = 0.002 ), and IL-12 p70 production ( p = 0.010 )
Cheng et al., Genes Dev 1996
:
TANK, a co-inducer with TRAF2 of TNF- and
CD 40L mediated
NF-kappaB activation
Iciek et al., J Immunol 1997
:
In addition to the
NF-kappaB/Rel complexes
induced by
CD40L , two nuclear complexes, each which contain both STAT6 and NF-kappaB/Rel proteins, are induced in splenic B cells by a combination of CD40L and IL-4, and bind to the CD40L/IL-4-responsive region of the germline epsilon promoter
Bretschneider et al., Biochem Biophys Res Commun 1997
:
Stimulation of resting cells by thrombin ( 10 nM ) or
TRAP ( 10-100 microM )
resulted in a comparable time dependent activation of
NFkappaB as detected by Western blotting and electrophoretic mobility shift assay ( EMSA ) of nuclear extracts
Francis et al., Int Immunol 1998
:
However, with continued stimulation RelB completely disappeared from anti-Ig stimulated kappaB binding material, but remained a component of
CD40L induced
NF-kappaB