Gene interactions and pathways from curated databases and text-mining

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NOS2 — PPARA

Text-mined interactions from Literome

Giri et al., J Immunol 2004 : Ligands for peroxisome proliferator activated receptor gamma ( PPARgamma ), such as 15-deoxy-12,14-PGJ2 ( 15d-PGJ2 ), have been proposed as a new class of anti-inflammatory compounds because 15d-PGJ2 was able to inhibit the induction of inflammatory response genes such as inducible NO synthase (iNOS) and TNF ( TNF-alpha ) in a PPAR dependent manner in various cell types
Paukkeri et al., Br J Pharmacol 2007 : The aim of the present study was to investigate the role of PPARalpha in the regulation of NO production and iNOS expression in activated macrophages
Liu et al., Biomaterials 2013 (Brain Ischemia) : Furthermore, CBSA-PEG-TIIA-NPs significantly decreased the mRNA expressions of iNOS and p38MAPK, upregulated PPAR? expression, and inhibited the protein levels of iNOS , GFAP and p38MAPK phosphorylation