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CD4 — IRF6
Text-mined interactions from Literome
Neate et al., Clin Exp Immunol 1992
:
However, in the
presence of
LPS ( 1 microgram/ml )
CD4 expression was reduced to undetectable levels while the expression of IL-2R and MO3 was induced to maximal density
Shirai et al., J Clin Immunol 2004
:
Thus, the low expression of functioning
LPS receptor molecules and
induction of IL-10 producing
CD4 ( + ) CD25 ( + ) lymphocytes by indigenous LPS may play a central role in the maintenance of colonic immunological homeostasis
Correa et al., J Leukoc Biol 2009
(Crohn Disease) :
Study of IL-10 production by isolated cell subsets showed that DCs, but not
CD4 ( + ) T cells, from penetrating Crohn 's disease produced significantly less IL-10 in
response to
LPS
Mnasria et al., Pathol Biol (Paris) 2011
:
Anti-CD25 treatment reduced the ability of
LPS-DC to
induce allogeneic
CD4 ( + ) T cell proliferation as compared to LPS matured DC
Xuan et al., Cell Physiol Biochem 2010
:
Both
LPS- and GA-stimulated DCs
enhanced CD4 ( + ) T cell proliferation but the profile of cytokines produced in allo-MLR was different
Nie et al., Clin Immunol 2012
:
To gain insight into the molecules involved, we set up an in vitro system in which
lipopolysaccharide (LPS) stimulated MCs and
CD4 ( + ) T cells were co-cultured
Biswas et al., J Exp Med 2012
(Autoimmune Diseases...) :
In
CD4 ( + ) T helper cells,
IRF4 plays an essential role in the regulation of IL-21 production, whereas in B cells it controls class switch recombination and plasma cell differentiation
Tincati et al., Clin Dev Immunol 2012
(HIV Infections) :
While no differences in the proportion of
LPS stimulated
CD4+CD38+ cells were recorded amongst HIV positive subgroups, CD8+CD38+ cells were more elevated in patients with lower CD4+ recovery on HAART ( i.e., LR and IR )
Lin et al., Cancer prevention research (Philadelphia, Pa.) 2012
(Carcinoma, Hepatocellular...) :
Reduction of endotoxin using antibiotics regimen or genetic ablation of TLR4 in mice significantly alleviate Con A-induced liver injury by inhibiting the infiltration of T lymphocytes into the liver and the activation of CD4 ( + ) T lymphocytes as well as the production of T helper 1 cytokines ; in contrast, exogenous
LPS can
promote Con A-induced hepatitis and
CD4 ( + ) T cells activation in vivo and in vitro
Ooi et al., Proc Natl Acad Sci U S A 2012
(Glomerulonephritis...) :
Transfer of an MPO ( 409-428 ) -specific
CD4 ( + ) T-cell clone to Rag1 ( -/- ) mice
induced focal necrotizing glomerulonephritis when glomerular MPO deposition was induced either by passive transfer of MPO-ANCA and
LPS or by planting MPO ( 409-428 ) conjugated to a murine antiglomerular basement membrane mAb
Nolte-'t Hoen et al., J Leukoc Biol 2013
:
Finally, we show that cognate interaction between
LPS stimulated DC and
CD4 T cells affects both the quantity and quality of LPS DC-derived EVs present in the culture supernatant
Herbein et al., Clin Exp Immunol 1995
:
The decreased macrophage
CD4 expression
induced by
LPS was blocked by MoAbs directed against human TNF-alpha and IL-1 beta, demonstrating that LPS acts on CD4 expression through induction of endogenous TNF-alpha and IL-1 beta
Kurita-Ochiai et al., Infect Immun 1999
:
These data suggest that
LPS , in combination with butyric acid, potentiates CD3 ( + ) PBMC T-cell apoptosis and
plays a role in the apoptotic depletion of
CD4 ( + ) and CD8 ( + ) cells