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EPHB2 — SPRED1

Text-mined interactions from Literome

Nonami et al., J Biol Chem 2004 (MAP Kinase Signaling System) : Spred-1 negatively regulates interleukin-3 mediated ERK/mitogen activated protein ( MAP ) kinase activation in hematopoietic cells ... In IL-3 dependent Ba/F3 cells expressing c-kit, forced expression of Spred-1 resulted in a reduced proliferation rate and ERK activation in response to not only SCF but also IL-3 ... In contrast, DeltaC Spred augmented IL-3 induced cell proliferation and ERK activation ... These data suggest that Spred-1 negatively regulates hematopoiesis by suppressing not only SCF induced but also IL-3 induced ERK activation
Nonami et al., Genes Cells 2005 : These data suggest that Spred-1 inhibits ERK activation in collaboration with Cav-1
Taniguchi et al., Mol Cell Biol 2007 : In cultured cells, the overexpression of Spred-1 or Spred-2 strongly suppressed vascular endothelial growth factor-C ( VEGF-C ) /VEGF receptor (VEGFR)-3 mediated ERK activation, while Spred-1/2-deficient cells were extremely sensitive to VEGFR-3 signaling
Phoenix et al., Genes Dev 2010 (Periventricular Nodular Heterotopia) : Spred1 , a negative regulator of Ras-MAPK-ERK , is enriched in CNS germinal zones, dampens NSC proliferation, and maintains ventricular zone structure
García-Domínguez et al., PloS one 2011 (MAP Kinase Signaling System) : We therefore found that ectopic overexpression in HeLa cells of human Sprouty2, or human Spred1 or 2, inhibits ERK1/2 and Elk-1 activation triggered by the cyclopentenone prostanoids PGA ( 1 ) and 15d-PGJ ( 2 )
Kachroo et al., Br J Cancer 2013 (Prostatic Hyperplasia...) : In functional assays, SPRED2 overexpression reduced ERK phosphorylation and inhibited prostate cancer cell proliferation and migration in response to different growth factors and full-media stimulation ( P < 0.001 )