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PTGS2 — RHO

Text-mined interactions from Literome

Slice et al., J Biol Chem 1999 : Galpha(13) stimulates Rho dependent activation of the cyclooxygenase-2 promoter
Slice et al., Biochem Biophys Res Commun 2000 : Differential regulation of COX-2 transcription by Ras- and Rho-family of GTPases ... This demonstrates Rho dependent transactivation of the COX-2 promoter through novel trans acting elements and suggests that, in NIH 3T3 cells, signaling by small GTPases that result in COX-2 expression is not through a sequential pathway from Cdc42 to Rac to Rho, but rather through independent, parallel signaling pathways
Hahn et al., Biochem J 2002 : The role of Rho proteins in lysophosphatidic acid (LPA) mediated induction of cyclo-oxygenase-2 (Cox-2) was investigated in renal mesangial cells
Slice et al., J Cell Physiol 2003 (Calcium Signaling) : Galphaq signaling is required for Rho dependent transcriptional activation of the cyclooxygenase-2 promoter in fibroblasts ... However, the specific role of heterotrimeric guanine nucleotide binding regulatory proteins ( G-proteins ) that are coupled to the GRP receptor in Rho dependent COX-2 expression has not been elucidated ... Activation of endogenous Rho by expression of Onco-lbc or expression of Rho A Q63L resulted in COX-2 promoter activation in Galpha ( q/11 ) deficient cells ... Inhibition of Rho by Clostridium botulinum C3 toxin blocked COX-2 promoter induction
Schmeck et al., Inflammation 2003 : Rho protein inhibition blocks cyclooxygenase-2 expression by proinflammatory mediators in endothelial cells
Chang et al., J Cell Biochem 2005 : Here we investigate the role of coordinate activation of Ras and Rho GTPases in the induction of COX-2 ... Together, our data suggest that constitutively active oncogenic Ras and Rho coordinately stimulate COX-2 expression whereas transient activation of Ras but not RhoA or Rac1 mediates the induction of COX-2 in response to serum
Hirota et al., Am J Physiol Gastrointest Liver Physiol 2012 : However, inhibition of either Src tyrosine kinase signaling by PP2, Rho kinase signaling by Y27632, or phosphatidylinositol 3 (PI3) kinase signaling by LY294002 prevented 2fLI induced COX-2 expression