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BAX — IFNG
Text-mined interactions from Literome
Marselli et al., J Clin Endocrinol Metab 2001
:
IL-1beta,
interferon gamma , and TNF alpha
caused no major change in either islet cell survival or Bcl-2 and
Bax mRNA expression after a 12-h incubation ; however, a marked increase in the amount of dead cells, with a major decrease of Bcl-2 mRNA expression, was observed after 72 h
Tesfaigzi et al., J Immunol 2002
(Eosinophilia...) :
IFN-gamma caused
Bax expression in IL-13 induced MCM in microdissected airway cultures ... Together, these data demonstrate that reduced IL-13 levels were sufficient to elicit maximum MCM, that
IFN-gamma induces
Bax in metaplastic mucus cells, and that Bax plays a critical role in the resolution of MCM, but not in the resolution of eosinophils
Liu et al., Cytokine 2003
:
Effect of
IFNgamma on caspase-3, Bcl-2 and
Bax expression, and apoptosis in rabbit placenta
Xiang et al., Am J Respir Cell Mol Biol 2008
(Metaplasia) :
These studies show that allergen induced MCM is a response to a combination of various cytokines at defined concentrations and that
IFN-gamma requires
Bax for the resolution of MCM
Guan et al., Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2009
:
The results suggest that HeLa apoptosis was induced by tumor necrosis factor-a and
interferon -gamma , and the increasing expression of P53 may
induce the expression of
Bax and prevent the expression of Bcl-2, via the mitochondrial induction of cell apoptosis