Brenneman et al., Brain Res 1999
:
VIP or DAPTA treatment of astrocyte cultures resulted in the release of macrophage inflammatory protein-1alpha ( MIP-1alpha ) and RANTES, beta chemokines known to block gp120 interactions with microglial chemokine receptors
Pozo et al., Cytokine 2002
:
In the present work, we studied the effect of VIP and PACAP on the CC chemokine macrophage inflammatory protein-1 alpha ( MIP-1alpha ) production in LPS stimulated RAW 264.7 macrophage cell line ... VIP and PACAP inhibited the production of MIP-1alpha in a dose dependent manner and over a broad spectrum of LPS concentrations ... By using selective PKA and PKC inhibitors and cAMP mimicked agents, we demonstrated a cAMP dependent signalling pathway for the inhibitory effect of VIP/PACAP on MIP-1alpha production, although a minor non mediated cAMP pathway was also involved
Ivanovska et al., Immunol Lett 2007
(Inflammation) :
VIP diminished the level of RANTES and MIP-1alpha in peritoneal exudate and circulation