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IRAK3 — TNF
Text-mined interactions from Literome
Ferlito et al., J Leukoc Biol 2001
(Leukemia, Monocytic, Acute...) :
However, neither
TNF-alpha nor IL-1beta
induced IRAK degradation or stimulated TNF-alpha or TxB2 production in naive cells
del Fresno et al., Nitric Oxide 2004
:
It is known that NO induces the expression of TNF-alpha in monocytes and we found that exposure to
TNF-alpha induced
IRAK-M mRNA expression in human monocytes within 2 h of stimulation
Kim et al., J Biol Chem 2005
(Inflammation) :
Importantly, endogenous
mPLK/IRAK was activated in
response to
TNF-alpha or interleukin 1 treatment of primary adipose cells
van 't Veer et al., J Immunol 2007
(Endotoxemia) :
In vitro studies in whole blood showed that
IRAK-M up-regulation by LPS is largely
dependent on
TNF-alpha
Kobayashi et al., J Immunol 2011
(Peritonitis...) :
Without CASP-6 expression, PMN stimulation fails to cleave
IRAK-M , degrade I?Ba, or
induce TNF-a
Nguyen et al., Am J Physiol Lung Cell Mol Physiol 2012
(Inflammation) :
Surfactant mediated upregulation of
IRAK-M in macrophages
suppresses TLR4 mediated
TNF-a and IL-6 production in response to LPS, and IRAK-M knockdown by small interfering RNA reverses this suppression