Gene interactions and pathways from curated databases and text-mining

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IRAK3 — TNF

Text-mined interactions from Literome

Ferlito et al., J Leukoc Biol 2001 (Leukemia, Monocytic, Acute...) : However, neither TNF-alpha nor IL-1beta induced IRAK degradation or stimulated TNF-alpha or TxB2 production in naive cells
del Fresno et al., Nitric Oxide 2004 : It is known that NO induces the expression of TNF-alpha in monocytes and we found that exposure to TNF-alpha induced IRAK-M mRNA expression in human monocytes within 2 h of stimulation
Kim et al., J Biol Chem 2005 (Inflammation) : Importantly, endogenous mPLK/IRAK was activated in response to TNF-alpha or interleukin 1 treatment of primary adipose cells
van 't Veer et al., J Immunol 2007 (Endotoxemia) : In vitro studies in whole blood showed that IRAK-M up-regulation by LPS is largely dependent on TNF-alpha
Kobayashi et al., J Immunol 2011 (Peritonitis...) : Without CASP-6 expression, PMN stimulation fails to cleave IRAK-M , degrade I?Ba, or induce TNF-a
Nguyen et al., Am J Physiol Lung Cell Mol Physiol 2012 (Inflammation) : Surfactant mediated upregulation of IRAK-M in macrophages suppresses TLR4 mediated TNF-a and IL-6 production in response to LPS, and IRAK-M knockdown by small interfering RNA reverses this suppression