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IL6 — MYLIP
Text-mined interactions from Literome
Meng et al., Oncogene 2008
(Bile Duct Neoplasms...) :
Overexpression of
IL-6 reduced
miR-370 expression and reinstated MAP3K8 expression in vitro as well as in tumor cell xenografts in vivo
Stanczyk et al., Arthritis Rheum 2008
(Arthritis, Rheumatoid) :
Constitutive expression of both miR-155 and miR-146a was higher in RASFs than in those from patients with osteoarthritis ( OA ), and expression of
miR-155 could be further
induced by TNFalpha,
interleukin-1beta , lipopolysaccharide, poly ( I-C ), and bacterial lipoprotein
Brock et al., Circ Res 2009
(Carcinoma, Hepatocellular...) :
Because IL-6 signaling is mainly mediated by STAT3 ( signal transducer and activator of transcription 3 ), the expression of STAT3 was knocked down by small interfering RNA, which abolished the
IL-6 mediated expression of
miR-17/92
Bhaumik et al., Aging 2009
:
Indeed, ectopic expression of
miR-146a/b in primary human fibroblasts
suppressed IL-6 and IL-8 secretion and downregulated IRAK1, a crucial component of the IL-1 receptor signal transduction pathway
Larner-Svensson et al., Respir Res 2010
:
Functional studies indicated that IL-1beta induced
miR-146a expression does not negatively
regulate IL-6 and IL-8 release or basal proliferation ... Unlike previous reports, studies using miRNA inhibitors showed that
miR-146a expression did not
regulate IL-6 and IL-8 release or proliferation and suggest miR-146a function and mechanism is cell-type dependent
Majid et al., Cancer 2010
(Neoplasm Invasiveness...) :
In this study, the authors demonstrated that
miRNA-205 (miR-205) induced the expression the
interleukin ( IL ) tumor suppressor genes IL24 and IL32 by targeting specific sites in their promoters
Stanczyk et al., Arthritis Rheum 2011
(Arthritis, Rheumatoid...) :
Enforced expression of
miR-203 led to significantly increased levels of MMP-1 and
IL-6 ...
Induction of
IL-6 by
miR-203 overexpression was inhibited by blocking of the NF-?B pathway
Meng et al., J Cell Mol Med 2012
(Carcinoma, Hepatocellular...) :
Knocking down
IL-6 and Twist in HSCs significantly
reduced let-7 and
miR-181 expression and subsequently inhibited chemoresistance and cell invasion
Sun et al., Blood 2011
(Sepsis) :
In vitro knockdown and overexpression studies demonstrated a critical and specific
role for
miR142-3p in regulating
IL-6 production by the DCs after LPS stimulation
Xu et al., J Biol Chem 2011
:
miR-365 , a novel negative
regulator of
interleukin-6 gene expression, is cooperatively regulated by Sp1 and NF-kappaB ... Furthermore,
miR-365 exhibited a greater negative regulatory
effect on
IL-6 than hsa-let-7a, a previously identified microRNA negatively regulating IL-6
Philippe et al., J Immunol 2012
(Arthritis, Rheumatoid) :
Taken together, our data point toward an important
role for
miR-19a/b in the regulation of
IL-6 and matrix metalloproteinase 3 release by controlling TLR2 expression, as well as provide evidence that miR-19a/b can act as negative regulators of inflammation in humans
Wang et al., Hepatology 2012
(Carcinoma, Hepatocellular...) :
Finally, this study showed that the activation of interleukin
(IL)-6-Stat3 signaling
caused the up-regulation of
miR-23a expression in HCC ... CONCLUSION : Based on these data, we conclude that gluconeogenesis is severely compromised in HCC by
IL6-Stat3 mediated
activation of
miR-23a , which directly targets PGC-1a and G6PC, leading to decreased glucose production
Rokavec et al., Mol Cell 2012
(Cell Transformation, Neoplastic...) :
IL6 mediated suppression of
miR-200c directs constitutive activation of inflammatory signaling circuit driving transformation and tumorigenesis
Vaporidi et al., Am J Physiol Lung Cell Mol Physiol 2012
(Disease Models, Animal...) :
In the inflammatory network,
IL-6 and SOCS-1,
regulated by miRNAs let-7 and
miR-155 , respectively, appeared as central nodes
Kumar et al., Cell Microbiol 2012
:
In addition, M.tb. induced
miR-155 inhibits expression of cyclooxygenase-2 (Cox-2) and
interleukin-6 (Il-6) , two modulators of the innate immune response
Bao et al., PloS one 2012
(Neoplasm Invasiveness...) :
The treatment of PCa cells with CDF, a novel Curcumin derived synthetic analogue previously showed anti-tumor activity in vivo,
inhibited the productions of VEGF and
IL-6 , and down-regulated the expression of Nanog, Oct4, EZH2 mRNAs, as well as
miR-21 under hypoxic condition
Wu et al., J Lipid Res 2012
(Hyperlipidemias) :
Abundance of
miR-181a attenuated ox-LDL induced CD83 and CD40 expression,
inhibited the secretion of
interleukin (IL)-6 and TNF-a, and up-regulated IL-10, an important anti-inflammatory cytokine that was inhibited by ox-LDL
Iyer et al., PloS one 2012
(Brain Diseases...) :
In addition, the expression of
IL-6 and COX-2 upon IL-1ß stimulation was
suppressed by increased levels of
miR-146a and increased by the reduction of miR-146a ... Modulation of
miR-146a expression
affected also the release of several cytokines such as
IL-6 and TNF-a
Rossato et al., Proc Natl Acad Sci U S A 2012
(Sepsis) :
Ectopic expression of
miR-187 consistently and selectively
reduces TNFa,
IL-6 , and IL-12p40 produced by LPS activated monocytes
An et al., PloS one 2012
(Cholangiocarcinoma) :
In addition, we show that
IL-6 induces a time dependent silencing of
miR-370 ... Our data indicate that the paternal allele of miR-370 is normally silenced through genomic imprinting and that the overexpression of
IL-6 in CCA effectively
suppresses the expression of
miR-370 from the maternal allele, lending support to the theory that miR-370 silencing in human CCA follows a classic two-hit mechanism
Rosenberger et al., J Immunol 2012
(Melanoma, Experimental...) :
miR-451 levels are themselves
increased by
IL-6 and type I IFN, potentially forming a regulatory loop
Wang et al., Biochem Biophys Res Commun 2013
:
Bioinformatics ' miR target analysis identified homology between miR-146a and the 3'-UTR of the human IL-6 mRNA, suggesting a potential
regulation of
IL-6 by
miR-146a
Xu et al., Mol Biol Rep 2013
(Obesity) :
Tumor necrosis factor-a (TNF-a), leptin and resistin, but not
interleukin-6 ,
caused downregulation of
hsa-miR-26b expression in adipocytes
Yu et al., Cancer Res 2013
:
Either
miR-145 suppression or ADAM17 overexpression in non-TICs/ALDH1 ( - ) CD44 ( - ) -HNC cells
increased expression and secretion of
interleukin (IL)-6 and soluble-IL-6 receptor ( sIL-6R )