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EGFR — F2R

Text-mined interactions from Literome

Sabri et al., Circ Res 2002 : Activation of PAR-1 leads to an increase in Src, Fyn, and epidermal growth factor receptor (EGFR) phosphorylation, with EGFR receptor transactivation by Src family kinases the major mechanism for PAR-1 dependent activation of extracellular signal regulated kinase, p38-mitogen activated protein kinase, and protein kinase B
Bergmann et al., Oncol Rep 2006 (Kidney Neoplasms) : PAR-type thrombin receptors in renal carcinoma cells : PAR1 mediated EGFR activation promotes cell migration ... Our data therefore document a regulatory role of PAR1 mediated EGFR transactivation in cancer cell chemotactic migration
Arora et al., Oncogene 2008 (Breast Neoplasms...) : PAR1 stimulated EGFR and ErbB2 transactivation leads to prolonged extracellular signal regulated kinase-1 and -2 signaling and promotes breast carcinoma cell invasion ... We also show that PAR1 signaling through Galpha ( i/o ) and metalloprotease activity is critical for ErbB transactivation and cellular invasion
Fujimoto et al., BMC cancer 2010 (Neoplasm Invasiveness...) : We have shown that activation of NF-kappaB and EGFR phosphorylation initially were triggered by the activation of PAR1 with alpha-thrombin