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NF1 — RPTOR

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of 19 proteins (association, anti tag coimmunoprecipitation) Li et al., Immunity 2011

Text-mined interactions from Literome

Hegedus et al., Cancer Res 2008 (Disease Models, Animal...) : Because neurofibromin negatively regulates mammalian target of rapamycin (mTOR) signaling , we showed that pharmacologic mTOR inhibition in vivo led to decreased tumor cell proliferation in a dose dependent fashion associated with a decrease in tumor volume
Banerjee et al., Cancer Res 2010 : The NF1 gene product neurofibromin negatively regulates Ras and mammalian target of rapamycin (mTOR) signaling , prompting clinical trials to evaluate the ability of Ras and mTOR pathway inhibitors to arrest NF1 associated tumor growth