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Vertegaal et al., Cell Signal 2000
:
In agreement with our previous finding that
p90 ( rsk1 ) is
essential for TPA induced activation of
NF-kappaB in Adenovirus 5E1 transformed Baby Rat Kidney cells, we now report that the MEK/ERK/p90 ( rsk1 ) inhibitor U0126 efficiently blocks TPA induced IkappaBalpha processing in these cells
Minsavage et al., J Pharmacol Exp Ther 2007
:
Thus, disruption of
p53/p90RSK mediated
NF-kappaB signaling and activation of ARE/EpRE pathways may be effective strategies to delineate mechanisms of action of BFA induced inflammation and cell death signaling in immortalized versus normal skin systems