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NFKB1 — RENBP
Text-mined interactions from Literome
Neumann et al., FEBS Lett 1999
:
Hyaluronic acid with a molecular weight above 1.2 MDa ( HMW-HA ) inhibits the
AGE induced activation of the transcription factor
NF-kappaB and the NF-kappaB regulated cytokines interleukin-1alpha, interleukin-6 and tumor necrosis factor-alpha
Lal et al., Kidney Int 2002
:
NF-kappaB was dose-dependently
activated by
AGE ... Antioxidants, vitamin E and nitecapone, prevented
AGE dependent
NF-kappaB activation and normalized PKC activity and associated TGF-beta1 transcription
Morcos et al., Diabetes 2002
(Diabetes Mellitus, Type 2...) :
To further prove an
AGE/CML induced
NF-kappaB activation in pTECs, NF-kappaB activation was studied in cultured human pTECs by electrophoretic mobility shift assays ( EMSAs ) and Western blot ... The
AGE- and CML dependent
activation of NF-kappaBp65 and
NF-kappaB dependent IL-6 expression could be inhibited using the soluble form of the receptor for AGEs (RAGE) ( soluble RAGE [ sRAGE ] ), RAGE-specific antibody, or the antioxidant thioctic acid ... The findings that excreted pTECs demonstrate activated NF-kappaB and IL-6 antigen and that
AGE-albumin and CML
lead to a perpetuated activation of
NF-kappaB in vitro infer that a perpetuated increase in proinflammtory gene products, such as IL-6, plays a role in damaging the renal tubule
Zhang et al., Di Yi Jun Yi Da Xue Xue Bao 2003
:
NF-kappa B could be
activated by
AGE-HSA in a time- and dose dependent manner, and the results obtained from immunochemical staining were consistent with those from EMSA
Seki et al., Metabolism 2003
(Arteriosclerosis) :
To examine possible mechanisms for this effect, we studied nuclear factor-kappa B (NF-kappaB) activation and the tyrosine phosphorylation pathway ;
AGE stimulated
NF-kappaB activity, but phosphorylation of the platelet derived growth factor ( PDGF ) receptor was unchanged
Lu et al., Proc Natl Acad Sci U S A 2004
(Inflammation) :
However,
AGE stimulated
NF-kappaB activity and mitogen activated protein kinase ( MAPK ) ( p44/42 ) phosphorylation were found markedly suppressed in R1-MC. Additionally, AGE stimulated macrophage chemotaxis protein 1 and RAGE overexpression were abolished in R1-MC
De Oliveira et al., J Lab Clin Med 2005
(Diabetes Mellitus, Type 2...) :
In the presence of insulin ( 10-100 nmol/L ), the
stimulation of
NF-kappaB protein expression by
AGE-BSA ( 100 microg/mL ) was decreased, whereas the expression of PPAR-gamma, protein was enhanced ... 15-Deoxyprostaglandin J2, a direct activator of PPAR-gamma, decreased
AGE-BSA stimulated
NF-kappaB expression
Zhao et al., Di Yi Jun Yi Da Xue Xue Bao 2005
:
A fusion protein with a molecular weight of about 45 kD was purified, which could interact with anti-RAGE antibody and AGE and block
AGE induced
nuclear factor (NF)-kB activation in the endothelial cells
Harashima et al., Biochem J 2006
(Diabetes Mellitus, Experimental...) :
A transfection experiment revealed that the mRNA was actually translated as deduced to yield the secretory protein working as a decoy in
AGE induced
NF-kappaB ( nuclear factor kappaB ) activation
Schiekofer et al., Exp Clin Endocrinol Diabetes 2006
(Diabetes Complications...) :
Postprandial mononuclear
NF-kappaB activation is
independent of the
AGE-content of a single meal ... Postprandial mononuclear
NF-kappaB activation after a single meal is
independent of the
AGE-content of the ingested protein
Hein et al., Clin Chim Acta 2006
(Bone Resorption...) :
The
AGE-RAGE interaction additionally
induces activation of
nuclear factor kB (NF-kB) in RAGE bearing cells ( e.g., cells participating in bone turnover )
San Martin et al., Free Radic Biol Med 2007
(Vascular Diseases) :
AGE stimulated
NF-kappaB activity was abolished by DPI and the superoxide scavenger MnTBAP
Sayed et al., Phytother Res 2007
:
Thymoquinone decreases
AGE induced
NF-kappaB activation in proximal tubular epithelial cells ... A significant reduction of
AGE induced
NF-kappaB-activation and Il-6 expression was observed
Sun et al., Basic Res Cardiol 2009
:
AGE-HSA also promoted EPCs apoptosis and
inhibited EPCs migration and increased
NF-kappaB activity, these effects could be significantly attenuated by the anti-RAGE neutralizing antibody as well as by p38 and ERK MAPK inhibitors
Deo et al., J Biochem Mol Toxicol 2009
:
Stimulation of human microvascular endothelial cells with
BSA-LMM-AGE-Cas complexes significantly
increased mRNA expression of the receptor of AGE (RAGE), galectin-3 ( AGE-R3 ), tumor necrosis factor alpha, and a marker of the mitogen activated protein kinase pathway ( MAPK-1 ), as well as
p65NF-kappaB activation
Hilmenyuk et al., Immunology 2010
(Food Hypersensitivity) :
Finally, expression of the receptor for advanced glycation endproducts ( RAGE ) and
activation of the transcription factor
nuclear factor (NF)-kappaB by
AGE were investigated
Ide et al., Microvasc Res 2010
(Diabetic Nephropathies) :
PEDF or neutralizing antibody raised against RAGE ( receptor for AGE ) was found to inhibit the
AGE induced oxidative stress generation and subsequent
NF-kappaB activation in mesangial cells
Kim et al., Age (Dordrecht, Netherlands) 2010
:
It is also known that
AGE enhance the generation of RS and that the binding of AGE to a specific AGE receptor ( RAGE )
induces the activation of the redox-sensitive, pro-inflammatory transcription factor,
nuclear factor-kappa B (NF-kB)