◀ Back to BCL2
BCL2 — MYC
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Lee et al., Oncogene 1999
:
In this manuscript, we show that
Bcl-2 targeted to the endoplasmic reticulum can
inhibit Myc- , but not etoposide induced apoptosis in the Rat-1 fibroblast cell line
Eischen et al., Mol Cell Biol 2001
:
Apoptosis triggered by
Myc induced suppression of Bcl-X ( L ) or
Bcl-2 is bypassed during lymphomagenesis ...
Myc activation suppresses Bcl-X ( L ) RNA and protein levels in cultures of primary myeloid and lymphoid progenitors, and Bcl-X ( L ) and
Bcl-2 expression is
inhibited by Myc in precancerous B cells from Emu-myc transgenic mice
Jiang et al., Cell Biol Int 2003
:
In addition,
c-Myc expression decreased and
Bcl-2 : Bax ratio
increased
Jin et al., J Biol Chem 2004
(Carcinoma, Small Cell...) :
Phosphorylation of
Bcl2 at Ser ( 70 )
promotes a direct interaction between Bcl2 and
c-Myc in the nucleus and on the outer mitochondrial membrane that significantly enhances the half-life of the c-Myc protein
Shiio et al., J Biol Chem 2006
:
We also found that
Myc reduces the expression of Bcl-2 and
Bcl-xL and that the apoptosis inducing stimuli up-regulate Bax expression
Jin et al., J Biol Chem 2006
:
Expression of nuclear targeted
Bcl2 enhances
c-Myc transcriptional activity with suppression of DNA repair but fails to prolong cell survival
Brunelle et al., J Cell Biol 2009
(Disease Models, Animal...) :
To compare the function of MCL-1 and BCL-2 in maintaining cancer survival, we constructed complementary mouse leukemia models based on
Emu-Myc expression in which either
BCL-2 or MCL-1 are
required for leukemia maintenance
Alarcon et al., Cancer Res 1996
:
This result suggests that
Bcl-2 does not
affect c-Myc function directly but acts downstream of c-Myc to inhibit apoptosis
Balajthy et al., Biochem Biophys Res Commun 1997
:
Protein bound cross-link content was significantly higher when apoptosis was
induced by
c-Myc while the concomitant presence of
Bcl-2 markedly reduced both apoptosis and enzymatic protein cross linking