◀ Back to JUN

HGF — JUN

Text-mined interactions from Literome

Rahmani et al., J Hepatol 1999 (Liver Neoplasms, Experimental) : We have investigated whether hepatocyte growth factor (HGF) induces differential AP-1 responses in normal and transformed rat hepatocytes, the 7777 cells ... HGF induced AP-1 activation leads to the formation of distinct dimers with different functional capacities in normal and transformed hepatocytes
Gao et al., Hepatology 1999 : HGF alone induced moderate levels of c-Jun-N-terminal kinase (JNK) and p44/p42 mitogen activated protein kinase ( MAPK ), resulting in moderate levels of AP-1-DNA binding activity ... HGF alone induced moderate levels of c-Jun-N-terminal kinase (JNK) and p44/p42 mitogen activated protein kinase ( MAPK ), resulting in moderate levels of AP-1-DNA binding activity ... LPS may contribute to hepatocyte replication by potentiating the effect of HGF on the activation of both AP-1-DNA binding and transcriptional activity
Seol et al., Oncogene 2000 (Carcinoma, Hepatocellular) : Stimulation of Hepa 1-6 cells with HGF resulted in a rapid and dramatic enhancement of the AP-1 binding activity as well as an overall increase in the level of AP-1 protein
Olsen et al., Biochem J 2000 : Involvement of activator protein 1 complexes in the epithelium-specific activation of the laminin gamma2-chain gene promoter by hepatocyte growth factor ( scatter factor )
García-Trevijano et al., Gastroenterology 2002 : Accordingly, we found that S-adenosylmethionine inhibits hepatocyte growth factor induced cyclin D1 and D2 expression, activator protein 1 induction , and hepatocyte proliferation
Bianchi et al., Arch Biochem Biophys 2002 (Melanoma, Experimental) : Since in B16-F1 cells HGF increased AP-1 activity and the mRNA expression of various AP-1 subunits, we may conclude that HGF induced transcription of mouse ODC was largely due to triggering of AP-1 pathway
Kobayashi et al., Kidney Int 2003 : Moreover, stimulation of the cells with HGF resulted in a marked increase ( five- to tenfold ) in phosphorylation of extracellular signal related protein kinase ( ERK ) 1/2 and p38 mitogen activated protein kinase ( MAPK ), but not of c-Jun NH2 terminal kinase (JNK)
Taniguchi et al., Mol Reprod Dev 2004 (MAP Kinase Signaling System) : HGF enhanced the phosphorylation of Elk-1 and c-Jun as nuclear transcription factors
Song et al., Hepatology 2007 : HGF rapidly induced c-Jun and small heterodimer partner mRNA and protein expression and increased phosphorylation of ERK1/2, JNK, and c-Jun ... Specific inhibitors of protein kinase C, extracellular signal regulated kinase 1/2 ( ERK1/2 ), and c-Jun N-terminal kinase (JNK) blocked HGF inhibition of CYP7A1 expression
Chen et al., PloS one 2012 : HGF mediated AP-1-luciferase activity and c-Jun binding to the AP-1 element was reduced by c-Met inhibitor, Ly294002, Akt inhibitor, and PP2
Rahimi et al., J Biol Chem 1996 : However, wortmannin did not influence HGF induced c-Jun expression