◀ Back to LOX

LOX — SMAD2

Pathways - manually collected, often from reviews:

• WikiPathways Canonical and Non-Canonical TGF-B signaling: Complex of SMAD4-SMAD2-SMAD3 → LOXL4/LOXL2/LOXL1/LOX (activation)

Text-mined interactions from Literome

Sethi et al., Invest Ophthalmol Vis Sci 2011 : This TGFß induction of LOX and LOXL expression was blocked by TGFß inhibitors as well as by inhibitors of the canonical Smad2 , -3, and -4 signaling and non-Smad JNK/AP-1 signaling pathways ( P < 0.05 )
Guadall et al., Front Biosci (Elite Ed) 2011 : Thus, our data support a role of Smad signaling and ROS in the up-regulation of LOX by hypoxia in endothelial cells