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BCL2 — HLA-DRB1

Text-mined interactions from Literome

Shankar et al., Mol Cancer Ther 2008 (Neoplasm Metastasis...) : DATS induced the expression of DR4 , DR5, Bax, Bak, Bim, Noxa, and PUMA and inhibited expression of Mcl-1, Bcl-2 , Bcl-X ( L ), survivin, XIAP, cIAP1, and cIAP2
Tiwary et al., PloS one 2010 : Knockdown studies using siRNAs to TRAIL, DR5, JNK and CHOP as well as chemical inhibitors of ER stress and caspase-8 showed that : i ) alpha-TEA activation of DR5/caspase-8 induces an ER stress mediated JNK/CHOP/DR5 positive amplification loop ; ii ) alpha-TEA downregulation of c-FLIP ( L ) protein levels is mediated by JNK/CHOP/DR5 loop via a JNK dependent Itch E3 ligase ubiquitination that further serves to enhance the JNK/CHOP/DR5 amplification loop by preventing c-FLIP 's inhibition of caspase-8 ; and ( iii ) alpha-TEA downregulation of Bcl-2 is mediated by the ER stress dependent JNK/CHOP/DR5 signaling
Ganapathy et al., PloS one 2010 (Neoplasm Metastasis...) : In xenografted tumors, resveratrol upregulated the expressions of TRAIL-R1/DR4, TRAIL-R2/DR5 , Bax and p27 ( /KIP1 ), and inhibited the expression of Bcl-2 and cyclin D1