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RHOA — S1PR2
Pathways - manually collected, often from reviews:
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NCI Pathway Database S1P2 pathway:
S1P/S1P2/G12/G13 complex (S1PR2-GNA12-GNA13)
→
RhoA (RHOA)
(modification, activates)
Okamoto et al., Mol Cell Biol 2000*, Sugimoto et al., Mol Cell Biol 2003, Ikeda et al., Biochem Biophys Res Commun 2004*, Gonda et al., Biochem J 1999
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NCI Pathway Database S1P2 pathway:
RhoA (RHOA)
→
S1P/S1P2/Gi complex (S1PR2-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1)
(modification, activates)
An et al., J Biol Chem 2000, Arikawa et al., J Biol Chem 2003, Gonda et al., Biochem J 1999
Evidence: mutant phenotype, assay
Text-mined interactions from Literome
Zhou et al., Am J Physiol Cell Physiol 2004
:
These results indicate that S1P induces 1 ) initial contraction mediated by S1P(2) and S1P(1) involving concurrent activation of PLC-beta1 and PLC-beta3 via Galpha ( q ) and Gbetagamma ( i ), respectively, resulting in inositol 1,4,5-trisphosphate dependent Ca ( 2+ ) release and MLCK mediated MLC(20) phosphorylation, and 2 ) sustained contraction exclusively mediated by
S1P(2) involving
activation of
RhoA via Galpha ( q ) and Galpha(13), resulting in Rho kinase- and PKC dependent MLC(20) phosphorylation
Grabski et al., Arterioscler Thromb Vasc Biol 2009
(Carotid Artery Injuries) :
S1P stimulated SMA expression requires
S1P2R dependent activation of
RhoA and mobilization of calcium from intracellular stores ... We further conclude that transcriptional regulation of SMA by S1P in vitro requires
S1P2R dependent activation of
RhoA and mobilization of calcium from intracellular calcium stores
Medlin et al., Arterioscler Thromb Vasc Biol 2010
:
These data indicate that
S1PR2 dependent activation of
RhoA in SMC is mediated by LARG and that this signaling mechanism promotes the differentiated SMC phenotype