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NCL — NPM1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Aurora B signaling: NSUN2 (NSUN2) → NSUN2/NPM1/Nucleolin complex (NSUN2-NPM1-NCL) (modification, collaborate)
  Sakita-Suto et al., Mol Biol Cell 2007*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Aurora B signaling: Nucleolin (NCL) → NSUN2/NPM1/Nucleolin complex (NSUN2-NPM1-NCL) (modification, collaborate)
  Sakita-Suto et al., Mol Biol Cell 2007*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Aurora B signaling: Nucleolin (NCL) → NPM1 (NPM1) (modification, collaborate) Sakita-Suto et al., Mol Biol Cell 2007*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Aurora B signaling: Aurora B (AURKB) → NSUN2/NPM1/Nucleolin complex (NSUN2-NPM1-NCL) (modification, activates)
  Sakita-Suto et al., Mol Biol Cell 2007*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Aurora B signaling: NSUN2/NPM1/Nucleolin complex (NSUN2-NPM1-NCL) → NPM1 (NPM1) (modification, collaborate) Sakita-Suto et al., Mol Biol Cell 2007*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Aurora B signaling: NSUN2 (NSUN2) → NSUN2/NPM1/Nucleolin complex (NSUN2-NPM1-NCL) (modification, collaborate)
  Sakita-Suto et al., Mol Biol Cell 2007*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Aurora B signaling: Nucleolin (NCL) → NSUN2/NPM1/Nucleolin complex (NSUN2-NPM1-NCL) (modification, collaborate)
  Sakita-Suto et al., Mol Biol Cell 2007*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Aurora B signaling: Nucleolin (NCL) → NPM1 (NPM1) (modification, collaborate) Sakita-Suto et al., Mol Biol Cell 2007*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Aurora B signaling: Aurora B (AURKB) → NSUN2/NPM1/Nucleolin complex (NSUN2-NPM1-NCL) (modification, activates)
  Sakita-Suto et al., Mol Biol Cell 2007*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Aurora B signaling: NSUN2/NPM1/Nucleolin complex (NSUN2-NPM1-NCL) → NPM1 (NPM1) (modification, collaborate) Sakita-Suto et al., Mol Biol Cell 2007*
  Evidence: mutant phenotype, assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: Complex of 46 proteins Hayano et al., J Biol Chem 2003
• IRef Biogrid Interaction: NCL — NPM1 (colocalization, biochemical) Havugimana et al., Cell 2012
• IRef Biogrid Interaction: NCL — NPM1 (colocalization, biochemical) Okuwaki et al., Nucleic Acids Res 2012*
• IRef Biogrid Interaction: NCL — NPM1 (physical association, affinity chromatography technology) Yu et al., Mol Cell Biol 2006*
• IRef Biogrid Interaction: NCL — NPM1 (physical association, affinity chromatography technology) Li et al., Eur J Biochem 1996*
• IRef Biogrid Interaction: NCL — NPM1 (direct interaction, pull down) Li et al., Eur J Biochem 1996*
• IRef Biogrid Interaction: NCL — NPM1 (physical association, affinity chromatography technology) Park et al., Protein J 2010
• MIPS CORUM TLE1 corepressor complex (MASH1 promoter-corepressor complex): TLE1 corepressor complex (MASH1 promoter-corepressor complex) complex (ACTB-HSPA4-MYH10-NCL-NONO-NPM1-PARP1-RAD50-TLE1-TOP2B) Ju et al., Cell 2004
• MIPS CORUM Nop56p-associated pre-rRNA complex: Nop56p-associated pre-rRNA complex complex (ACTA2-ACTG2-BRIX1-DDX21-DHX9-EBNA1BP2-EEF1A1-EEF2-FBL-GNL3-H1FX-HIST1H1D-HIST1H2BM-HNRNPA1-HNRNPM-HNRNPU-IGF2BP1-ILF2-ILF3-LUC7L2-LYAR-MYBBP1A-NAP1L1-NCL-NHP2L1-NOP58-NOP56-NOLC1-NPM1-PWP1-RBM28-RPL10-RPL10A-RPL11-RPL12-RPL13-RPL13A-RPL14-RPL15-RPL17-RPL18-RPL18A-RPL19-RPL21-RPL22-RPL23-RPL23A-RPL24-RPL26-RPL27-RPL27A-RPL28-RPL29-RPL3-RPL30-RPL31-RPL32-RPL35-RPL35A-RPL36-RPL36A-RPL37A-RPL39-RPL4-RPL5-RPL6-RPL7-RPL7A-RPL8-RPL9-RPLP0-RPLP1-RPLP2-RPS11-RPS12-RPS13-RPS14-RPS15-RPS15A-RPS16-RPS17-RPS18-RPS2-RPS23-RPS24-RPS29-RPS3A-RPS6-RPS7-RPS8-RPS9-RSL1D1-SCYL2-SLC25A5-SRP14-SRPK1-TCOF1-TOP1-TUBA1A-TUBB1-TUFM-U2AF1-U2AF2-YBX1) Hayano et al., J Biol Chem 2003
• MIPS CORUM TLE1 corepressor complex (MASH1 promoter-corepressor complex): TLE1 corepressor complex (MASH1 promoter-corepressor complex) complex (HSPA4-NCL-NONO-NPM1-PARP1-RAD50-TLE1-TOP2B) Ju et al., Cell 2004
• IRef Corum Interaction: Complex of NPM1-PARP1-NCL-HSPA4-TOP2B-TLE1-NONO-RAD50 (association, molecular sieving) Ju et al., Cell 2004
• IRef Corum Interaction: Complex of 209 proteins (association, anti tag coimmunoprecipitation) Hayano et al., J Biol Chem 2003
• IRef Corum Interaction: Complex of 31 proteins (association, anti tag coimmunoprecipitation) Ju et al., Cell 2004
• IRef Hprd Interaction: Complex of 2739 proteins (in vivo) Czubaty et al., Biochim Biophys Acta 2005
• IRef Hprd Interaction: NCL — NPM1 (two hybrid) Liu et al., Cancer Lett 1999*, Li et al., Eur J Biochem 1996*
• IRef Hprd Interaction: NCL — NPM1 (in vivo) Liu et al., Cancer Lett 1999*, Li et al., Eur J Biochem 1996*
• IRef Hprd Interaction: NCL — NPM1 (in vitro) Liu et al., Cancer Lett 1999*, Li et al., Eur J Biochem 1996*
• IRef Intact Interaction: Complex of 28 proteins (association, pull down) Czubaty et al., Biochim Biophys Acta 2005
• IRef Intact Interaction: Complex of 28 proteins (association, pull down) Czubaty et al., Biochim Biophys Acta 2005
• IRef Intact Interaction: Complex of 50 proteins (association, anti tag coimmunoprecipitation) Li et al., Mol Cell Biol 2003
• IRef Intact Interaction: Complex of 228 proteins (association, pull down) Blagoev et al., Nat Biotechnol 2003
• IRef Intact Interaction: Complex of 39 proteins (association, anti tag coimmunoprecipitation) Liu et al., Nature 2012
• IRef Intact Interaction: Complex of 168 proteins (association, cross-linking study) Byron et al., Proteomics 2012
• IRef Intact Interaction: Complex of 400 proteins (association, cross-linking study) Humphries et al., Science signaling 2009
• IRef Intact Interaction: Complex of 62 proteins (association, tandem affinity purification) Vandamme et al., Mol Cell Proteomics 2011
• IRef Intact Interaction: Complex of 72 proteins (physical association, molecular sieving) Bernhard et al., J Am Soc Mass Spectrom 2004
• IRef Intact Interaction: Complex of 114 proteins (association, anti tag coimmunoprecipitation) Höck et al., EMBO Rep 2007
• IRef Ophid Interaction: NPM1 — NCL (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Yang et al., Nucleic Acids Res 2002 : UV radiation induces the protein expression levels and RNA binding activity of NPM while nucleolin RNA binding activity increases after UV or ionizing radiation exposure
Inder et al., J Biol Chem 2009 (MAP Kinase Signaling System) : NPM and nucleolin both stabilize K-Ras levels on the plasma membrane, but NPM concurrently increases the clustered fraction of GTP-K-Ras