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HRAS — PLA2G4A

Text-mined interactions from Literome

Van Putten V et al., J Biol Chem 2001 (MAP Kinase Signaling System) : Stable expression of H-Ras increased expression of cPLA(2) and COX-2 protein ... Expression of constitutively active Raf did not increase either cPLA(2) or COX-2 promoter activity, but inhibition of the ERK pathway with pharmacological agents or expression of dominant negative ERK partially blocked the H-Ras mediated induction of cPLA(2) promoter activity ... Expression of dominant negative JNK kinases decreased cPLA(2) promoter activity in NSCLC cell lines and inhibited H-Ras mediated induction in normal epithelial cells, whereas expression of constructs encoding constitutively active JNKs increased promoter activity
Blaine et al., J Biol Chem 2001 (Carcinoma, Non-Small-Cell Lung...) : Mutations in any of these elements decreased basal and Ha-Ras induced cPLA(2) promoter activity in both normal lung epithelial cells, as well as steady state promoter activity in A549 cells, with a mutation in element -21/-18 completely eliminating all promoter activity