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CASP3 — NOTCH1
Text-mined interactions from Literome
Yao et al., Dig Liver Dis 2009
(Stomach Neoplasms) :
As the molecular mechanism involved, we showed over activated
Notch-1 partially
suppressed TNFalpha induced activation of
caspase-3 ... Our data indicate that over activated
Notch-1 significantly protects BGC-823 cells from TNFalpha induced apoptosis, and this effect is
mediated , at least in part, by decreasing activation of
caspase-3 independent of NF-kappaB
Garg et al., Gastroenterology 2011
(Colitis...) :
Inhibition of
Notch1 signaling significantly
reduced protein levels of active Notch1, p53, p21WAF1/Cip1, Bax-1,
active caspase-3 , as well as apoptosis, compared with controls