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WIF1 — WNT11
Pathways - manually collected, often from reviews:
-
KEGG Wnt signaling pathway:
WIF1
→
WNT1/WNT10A/WNT10B/WNT11/WNT16/WNT2/WNT2B/WNT3/WNT3A/WNT4/WNT5A/WNT5B/WNT6/WNT7A/WNT7B/WNT8A/WNT8B/WNT9A/WNT9B
(protein-protein, inhibition)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Taniguchi et al., Oncogene 2005
(Cell Transformation, Neoplastic...) :
TOPflash assay showed
WIF-1 inhibits
Wnt canonical signaling in these cell lines
Lin et al., Biochem Biophys Res Commun 2006
(Carcinoma...) :
Wnt inhibitory factor-1 (WIF-1) is a secreted antagonist of Wnt signaling and
acts through direct binding to
Wnt in the extracellular space
Lin et al., Hum Gene Ther 2007
(Melanoma...) :
Wnt inhibitory factor-1 (WIF-1) is a secreted antagonist of Wnt signaling and
acts through direct binding to
Wnt in the extracellular space
Hu et al., Brain Res Gene Expr Patterns 2008
:
Our data shows that the expression of Wif1 was very strong during embryonic development of the CNS and suggests that
Wif1 may
play an essential role in the spatial and temporal regulation of
Wnt signals
Nakaya et al., J Neurosci 2008
:
Injection of RNA encoding
WIF-1 , a secreted
inhibitor of
Wnt signaling, caused changes in the expression pattern of rx3 similar to those observed after Olfm1-MO injection
Tang et al., Mol Cancer Ther 2009
(Neoplasm Invasiveness...) :
WIF1 , a
Wnt pathway
inhibitor , regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells
Ding et al., World J Gastroenterol 2009
(Carcinoma, Hepatocellular...) :
DKK-3 and
WIF-1 acted as Wnt-antagonists and tumor suppressors, but hypermethylation of the gene promoter and low mRNA expression
activated Wnt signaling aberrantly and induced the development of HCC
Hu et al., Zhejiang Da Xue Xue Bao Yi Xue Ban 2010
:
Histological information of Wif1 expression during the development of the central nervous system has been reported in mouse, Xenopus and zebrafish and the strong embryonic expression suggests
Wif1 may
play an essential role in the spatial and temporal regulation of
Wnt signals in development of central nervous system
Yang et al., J Exp Clin Cancer Res 2010
(Astrocytoma...) :
Wnt inhibitory factor-1(WIF-1) acts as a Wnt-antagonists and tumor suppressor, but hypermethylation of WIF-1 gene promoter and low expression
activate Wnt signaling aberrantly and induce the development of various human tumors
Yang et al., Acta Biochim Biophys Sin (Shanghai) 2010
(Astrocytoma) :
Wnt inhibitory factor-1 (WIF-1) acts as a Wnt antagonist and tumor suppressor, but hypermethylation of WIF-1 gene promoter and low expression of WIF-1
activate Wnt signaling aberrantly and induce the development of several human tumors
Surmann-Schmitt et al., J Cell Physiol 2012
:
Conversely, CTGF does not interfere with
Wif-1 dependent inhibition of
Wnt signalling
Avanesov et al., PLoS Genet 2012
:
The role of glypicans in Wnt inhibitory factor-1 activity and the structural basis of
Wif1 's
effects on
Wnt and Hedgehog signaling
Kim et al., J Invest Dermatol 2013
(Hyperpigmentation...) :
Wnt signals
regulate skin pigmentation ; however,
WIF-1 is expressed in cultured skin keratinocytes and fibroblasts, but not in melanocytes