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ABL1 — RELA
Text-mined interactions from Literome
Mukhopadhyay et al., J Biol Chem 2002
:
The suppression of TNF induced NF-kappaB activation by Bcr-Abl was not restricted to MBA cells, because ectopic expression of
Bcr-Abl in human acute myeloid leukemia HL-60 cells also
blocked TNF induced
NF-kappaB activation
Kirchner et al., Exp Hematol 2003
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Mechanisms of
Bcr-Abl mediated
NF-kappaB/Rel activation ... In this paper we demonstrate
activation of
NF-kappaB/Rel by
Bcr-Abl and for the first time by v-Abl ... Furthermore, we investigated mechanisms of
NF-kappaB/Rel induction by
Bcr-Abl and v-Abl
Hanson et al., J Biol Chem 2003
:
Consistent with this, evidence has been presented that
NF kappa B activity is
required for Ras and
BCR-ABL to transform cells ... The data presented here indicate that
BCR-ABL expression in 32D myeloid cells or oncogenic Ras expression in murine fibroblasts
blocks the ability of tumor necrosis factor (TNF) to activate
NF kappa B
Han et al., Life Sci 2004
:
EMSA demonstrated that
ABL inhibited effectively the association of
NF-kappaB , which is necessary for the expression of iNOS and COX-2, with its binding motif in the promoter of target genes
Liu et al., Eur J Pharmacol 2007
(Inflammation) :
In addition,
ABL directly
inhibited the binding of active
NF-kappaB to specific DNA cis-element
Duncan et al., Mol Cancer Ther 2008
:
Additionally, we reported previously that
BCR-ABL activates the transcription factor
nuclear factor-kappaB (NF-kappaB) in a manner dependent on Ras and that inhibition of NF-kappaB by expression of a modified form of IkappaBalpha blocked BCR-ABL-driven tumor growth in a xenograft model ... These data indicate that blockage of
BCR-ABL induced
NF-kappaB activation via IkappaB kinase beta inhibition represents a potential new approach for treatment of Imatinib- or Dasatinib-resistant forms of chronic myelogenous leukemia
Hamdane et al., Oncogene 1997
:
Activation of p65
NF-kappaB protein by
p210BCR-ABL in a myeloid cell line ( P210BCR-ABL activates p65 NF-kappaB ) ... We have analysed the
effect of
p210BCR-ABL expression on
NF-kappaB activity in DA1 cells ( an IL-3 dependent murine myeloid progenitor cell line ) ... A specific
stimulation of
NF-kappaB activity by kinase-active wild-type
p210BCR-ABL has been evidenced by transcriptional activation assays