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NAMPT — NOS2

Text-mined interactions from Literome

Romacho et al., Diabetologia 2009 (Diabetes Mellitus...) : ePBEF/NAMPT/visfatin ( 10-250 ng/ml ) induced iNOS in a concentration dependent manner ... By using the respective ERK 1/2 and NF-kappaB inhibitors, PD98059 and pyrrolidine dithiocarbamate, we established that iNOS induction by ePBEF/NAMPT/visfatin required the consecutive upstream activation of ERK 1/2 and NF-kappaB ... However, exogenous nicotinamide mononucleotide, the product of NAMPT activity, mimicked NF-kappaB activation and iNOS induction by ePBEF/NAMPT/visfatin, while the NAMPT inhibitor APO866 prevented the effects of ePBEF/NAMPT/visfatin on iNOS and NF-kappaB
Kang et al., J Pineal Res 2013 : Melatonin inhibits visfatin induced inducible nitric oxide synthase expression and nitric oxide production in macrophages ... Here, we report the assessment of the role of visfatin in the regulation of iNOS gene expression in macrophages ... Our results also show that visfatin induced iNOS expression and NO production were significantly inhibited by melatonin, an effect that was closely associated with a reduction in phosphorylated JAK2/STAT3 levels and with the inhibition of p65 translocation into nucleus ... In conclusion, our data show, for the first time, that melatonin suppresses visfatin induced iNOS upregulation in macrophages by inhibiting the STAT3 and NF-?B pathways