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NOS2 — STAT3

Text-mined interactions from Literome

Yu et al., J Biol Chem 2003 : JAK2/STAT3 , not ERK1/2, mediates interleukin-6 induced activation of inducible nitric-oxide synthase and decrease in contractility of adult ventricular myocytes
Hierholzer et al., Am J Physiol Gastrointest Liver Physiol 2004 (Enteritis...) : Selective iNOS inhibition in shocked animals reduced the binding activity of NF-kappaB and Stat3 and reduced mRNA levels of ICAM-1, IL-6, and G-CSF
Yu et al., J Biol Chem 2004 : Flagellin induced expression of inducible nitric-oxide synthase but not IL-6, was abolished by blocking STAT activation with AG490, and was reduced by blocking STAT-3 activation with anti-IL-6
Saura et al., J Biol Chem 2006 : Stat3 mediates interleukin-6 [ correction of interelukin-6 ] inhibition of human endothelial nitric-oxide synthase expression
Ma et al., Int J Cancer 2008 (Carcinoma...) : These data suggest that nuclear accumulation of EGFR and STAT3 activation by IL-6 play the key role in iNOS expression and resultant DNA damage, leading to EBV mediated NPC
Kim et al., Free Radic Biol Med 2008 : The inhibition of STAT1 and STAT3 by EP prevented their translocation to the nucleus and consequently inhibited expression of iNOS and COX-2 by inhibiting STAT1- and STAT3 mediated transcriptional activity, followed by changes in chromatin conformation via deacetylation of histones H3 and H4 in both gene promoters
Park et al., Cytokine 2008 : We also found that downregulation of STAT3 using STAT3 siRNA resulted in suppression of the NO synthesis and iNOS expression
Broadbelt et al., American journal of physiology. Renal physiology 2009 (Ureteral Obstruction) : These data indicate that EGFR, NFkappaB, and STAT3 are required for human iNOS gene induction in response to pressure or EGF, indicating a similar mechanism of activation
Hao et al., Int J Radiat Biol 2010 : P6, a JAK inhibitor, reduced induction of iNOS and TNF-alpha, nuclear factor binding activity, and activation of STAT3 in EMF stimulated microglia
Youn et al., Nutr Cancer 2009 (Colitis...) : Oral administration of resveratrol or piceatannol ( 10 mg/kg body weight each ) for 7 constitutive days attenuated the DSS induced inflammatory injury, upregulation of iNOS expression, and activation of NF-kappaB, STAT3 , and ERK
Kou et al., Int Immunopharmacol 2011 : The inhibitions of STAT1 and STAT 3 by arctigenin prevented their translocation to the nucleus and consequently inhibited expression of iNOS , thereby suppressing the expression of inflammation associated genes, such as IL-1ß, IL-6 and MCP-1, whose promoters contain STAT binding elements
Puram et al., J Neurosci 2012 (Cell Transformation, Neoplastic...) : Endogenous STAT3 occupies the endogenous iNOS promoter and stimulates iNOS transcription in EGFRvIII expressing astrocytes ... STAT3 does not appear to control iNOS transcription in astrocytes deficient in the major glioblastoma tumor suppressor protein phosphatase and tensin homolog (PTEN), suggesting that STAT3 regulates iNOS transcription specifically in EGFRvIII expressing astrocytes
Qi et al., Inflamm Res 2013 : Baicalein suppressed the nuclear translocation of STAT1 and STAT3 and inhibited production of iNOS upon LPS-stimulation, resulting in the inhibition of releases of NO and pro-inflammatory cytokines such as IL-1ß, IL-6, and TNF-a, in a dose dependent manner