UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 complex (IGF1R-IGF1-IRS1-GNB2L1-GRB2-SHC1-SOS1) → PKC mu (PRKD1) (modification, activates) Hermanto et al., Mol Cell Biol 2002
Evidence: assay, physical interaction
NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc complex (IGF1R-IGF1-GRB2-SHC1-SOS1) → IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 complex (IGF1R-IGF1-IRS1-GNB2L1-GRB2-SHC1-SOS1) (modification, collaborate)
Hermanto et al., Mol Cell Biol 2002, Kiely et al., J Biol Chem 2005
Evidence: assay, physical interaction
NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 complex (IGF1R-IGF1-IRS1-GNB2L1-GRB2-SHC1-SOS1) → RACK1 (GNB2L1) (modification, collaborate) Hermanto et al., Mol Cell Biol 2002, Kiely et al., J Biol Chem 2005
Evidence: assay, physical interaction
NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 complex (IGF1R-IGF1-IRS1-GNB2L1-GRB2-SHC1-SOS1) → PKC delta (PRKCD) (modification, activates) Hermanto et al., Mol Cell Biol 2002
Evidence: assay, physical interaction