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APP — NOS3
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
de la Monte et al., J Neuropathol Exp Neurol 2007
(Disease Models, Animal...) :
Overexpression of
NOS3 in the brain
increased the levels of
APP , APP-Abeta, p53, Tau, glial fibrillary acidic protein, and peroxisome proliferator activated receptors ( PPAR) delta and gamma and decreased the levels of Hu ( neuronal marker ) mRNA, phosphorylated glycogen synthase kinase 3beta, ATP synthase, and choline acetyltransferase expression as demonstrated by real-time quantitative reverse transcribed polymerase chain reaction, Western blot analysis, or immunohistochemical staining
Austin et al., Circ Res 2010
(Alzheimer Disease) :
Inhibition of
endothelial nitric oxide synthase (eNOS) with the specific NOS inhibitor L-NAME ( N ( G ) -nitro-l-arginine methyl ester )
led to increased
APP and BACE1 ( ß-site APP cleaving enzyme1 ) protein levels, as well as increased secretion of the amyloidogenic peptide amyloid ß ( Aß ) ( control 10.93 ± 0.70 pg/mL ; L-NAME 168.21 ± 27.38 pg/mL ; P < 0.001 )
d'Uscio et al., Cardiovasc Res 2012
:
Overexpression of
APP significantly
impaired endothelium dependent relaxations to acetylcholine and phosphorylation of endothelial
nitric oxide synthase at Ser ( 1177 ) in aortas