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CTNNB1 — TYR
Text-mined interactions from Literome
Piedra et al., Mol Cell Biol 2003
:
We show here that interaction of
beta-catenin with alpha-catenin is
regulated by the phosphorylation of beta-catenin
Tyr-142
Miravet et al., Mol Cell Biol 2003
:
Our results also indicate that phosphorylation of
Tyr549 and the increased binding of plakoglobin to components of adherens junctions can
contribute to the upregulation of the transcriptional activity of the
beta-catenin-Tcf-4 complex observed in many epithelial tumor cells
Burks et al., Oncogene 2006
(Cell Transformation, Neoplastic) :
Tyr phosphorylation of alpha-catenin
enhances its translocation to the plasma membrane and its interaction with
beta-catenin , leading to enhanced actin polymerization and stabilization of adherens junction mediated intercellular adhesion, a phenomenon commensurate with loss of the transformation phenotype