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INS — PDK1

Text-mined interactions from Literome

Standaert et al., J Biol Chem 1999 : Also, insulin in situ and PIP ( 3 ) in vitro activated and stimulated autophosphorylation of a PKC-zeta mutant, in which threonine 410 is replaced by glutamate ( but not by an inactivating alanine ) and can not be activated by PDK-1
Grillo et al., Eur J Biochem 2000 : Using isolated adipocytes, we studied the effect of insulin and of an insulin mimicking agent peroxovanadate on the subcellular localization of PDK1
Oriente et al., J Biol Chem 2001 : PDK1 ( a phosphatidylinositol trisphosphate dependent kinase ) and Akt/protein kinase B (PKB) activation by insulin showed no difference in B2, F4, and in control L6hIR cells
Chen et al., Biochemistry 2001 : We now show that insulin stimulation of NIH-3T3 ( IR ) cells or rat adipose cells may significantly increase the intrinsic catalytic activity of PDK-1 ... Insulin stimulation of rat adipose cells also increased catalytic activity of endogenous PDK-1 immunoprecipitated from the cells ... Both insulin stimulated phosphorylation and activity of PDK-1 were inhibited by wortmannin and reversed by treatment with the phosphatase PP-2A ... Thus, the insulin stimulated increase in PDK-1 catalytic activity may involve PI 3-kinase- and phosphorylation dependent mechanisms
Yamada et al., Am J Physiol Endocrinol Metab 2002 : Thus membrane localization of PDK1 via its PH domain is essential for insulin signaling through the PDK1-PKB-GSK3alpha/beta pathway
Wick et al., Curr Drug Targets Immune Endocr Metabol Disord 2001 : Given its central role as the kinase upstream of those signaling pathways linked to P13K, the regulation of PDK1 by insulin and other factors is at the height of many of these investigations
Kim et al., Diabetes 2003 (Diabetes Mellitus...) : Insulin also stimulates PDK-1 activity approximately twofold with no impairment in obese or diabetic subjects
Seo et al., Mol Biol Cell 2005 : When SK-N-SH cells were pretreated with the NADPH oxidase inhibitor diphenyleneiodonium chloride before insulin stimulation, insulin mediated translocation of PDK-1 to the membrane fraction and phosphorylation of Akt were remarkably reduced, whereas PI-3 kinase activity was not changed significantly
Seong et al., J Biol Chem 2005 : Insulin enhanced a physical association between PDK1 and STRAP in intact cells, but this insulin induced association was prevented by wortmannin, a phosphatidylinositol 3-kinase inhibitor
Oak et al., Am J Physiol Endocrinol Metab 2006 (Fetal Growth Retardation) : Insulin stimulated increases in p-PDK-1 ( P < 0.05 ) and p-Akt ( P < 0.0007 ), with no increase in p-PKCzeta, were seen in both CM/SP and SM/SP groups
Riojas et al., J Biol Chem 2006 : In the present study, we show that PDK1 undergoes insulin stimulated and phosphatidylinositol 3-kinase dependent phosphorylation at Ser244 in the activation loop and at a novel site : Ser163 in the hinge region between the two lobes of the kinase domain
Dey et al., Biochem Biophys Res Commun 2007 : In the present investigation we have demonstrated that palmitate significantly ( p < 0.001 ) inhibited insulin stimulated phosphorylation of PDK1 , the key insulin signaling molecule
Yao et al., Am J Physiol Regul Integr Comp Physiol 2008 (Insulin Resistance...) : In EtOH compared with pair fed and control offspring, basal and pyruvate induced blood glucose was increased, insulin induced PDK1 , Akt, and PKCzeta phosphorylation was reduced, and expression of PTEN and TRB3 was increased while their acetylation status was decreased in association with increased HDAC and decreased HAT activities
Cho et al., International journal of molecular sciences 2008 : This review focuses on the contribution of natural inhibitor or compound in our understanding of the mechanism by which insulin induces , especially in PI3K/PDK1/PKB signaling
Goenaga et al., Mol Endocrinol 2009 : We further demonstrated that insulin induced Grb14-PDK1 interaction is required in addition to Grb14-IR binding to mediate maximal inhibition of insulin signaling
Biswas et al., Mol Cell Biochem 2010 (Diabetes Mellitus, Experimental...) : We have isolated mahanine, a carbazole alkaloid, from the leaves of Murraya koenegii that prevented palmitate induced inhibition of insulin stimulated phosphorylation of IRbeta, PI3K, PDK1 , and Akt in L6 myotubes
Nemoto et al., Am J Physiol Heart Circ Physiol 2011 (Diabetes Mellitus, Type 2...) : The insulin stimulated phosphorylation levels of Src/PDK1/Akt/eNOS , but not of Pyk2, were decreased by PP2 in control and losartan treated GK, but not in GK, aortas