◀ Back to HSP90AA1
AR — HSP90AA1
Pathways - manually collected, often from reviews:
-
KEGG Pathways in cancer:
Complex of AR-HSP90AA1-HSP90AB1-HSP90B1
→
Complex of AR
(protein-protein, activation)
-
KEGG Prostate cancer:
Complex of AR-HSP90AA1-HSP90AB1-HSP90B1
→
Complex of AR
(protein-protein, activation)
-
KEGG Prostate cancer:
None
→
Complex of AR-HSP90AA1-HSP90AB1-HSP90B1
(protein-compound, activation)
-
KEGG Prostate cancer:
None
→
Complex of AR-HSP90AA1-HSP90AB1-HSP90B1
(protein-compound, activation)
-
KEGG Prostate cancer:
None
→
Complex of AR-HSP90AA1-HSP90AB1-HSP90B1
(protein-compound, activation)
-
NCI Pathway Database Regulation of Androgen receptor activity:
Hsp90 (HSP90AA1)
→
AR/T-DHT complex (AR)
(modification, collaborate)
Nemoto et al., J Steroid Biochem Mol Biol 1992*
Evidence: physical interaction, other species
-
NCI Pathway Database Regulation of Androgen receptor activity:
Hsp90 (HSP90AA1)
→
T-DHT/AR/Hsp90 complex (AR-HSP90AA1)
(modification, collaborate)
Nemoto et al., J Steroid Biochem Mol Biol 1992*
Evidence: physical interaction, other species
-
NCI Pathway Database Regulation of Androgen receptor activity:
AR/T-DHT complex (AR)
→
T-DHT/AR/Hsp90 complex (AR-HSP90AA1)
(modification, collaborate)
Nemoto et al., J Steroid Biochem Mol Biol 1992*
Evidence: physical interaction, other species
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
AR
—
HSP90AA1
(physical association, affinity chromatography technology)
Gibbs et al., Proc Natl Acad Sci U S A 2009*
-
IRef Biogrid Interaction:
AR
—
HSP90AA1
(direct interaction, two hybrid)
Wolf et al., Arch Biochem Biophys 2007*
-
IRef Biogrid Interaction:
AR
—
HSP90AA1
(physical association, affinity chromatography technology)
Veldscholte et al., Biochemistry 1992*
-
IRef Biogrid Interaction:
AR
—
HSP90AA1
(direct interaction, pull down)
Nemoto et al., J Steroid Biochem Mol Biol 1992*
-
IRef Biogrid Interaction:
AR
—
HSP90AA1
(physical association, affinity chromatography technology)
Zoubeidi et al., Cancer Res 2007*
-
IRef Biogrid Interaction:
AR
—
HSP90AA1
(physical association, affinity chromatography technology)
DaSilva et al., Cancer Res 2009*
-
IRef Biogrid Interaction:
AR
—
HSP90AA1
(direct interaction, pull down)
Chymkowitch et al., EMBO J 2011
-
IRef Dip Interaction:
AR
—
HSP90AA1
(physical association, anti bait coimmunoprecipitation)
Gibbs et al., Proc Natl Acad Sci U S A 2009*
-
IRef Hprd Interaction:
AR
—
HSP90AA1
(in vitro)
Nemoto et al., J Steroid Biochem Mol Biol 1992*
-
IRef Ophid Interaction:
AR
—
HSP90AA1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Saporita et al., Prostate 2007
(Neoplasms, Hormone-Dependent...) :
The
Hsp90 inhibitor, 17-AAG,
prevents the ligand independent nuclear localization of
androgen receptor in refractory prostate cancer cells
O'Malley et al., Prostate 2012
(Disease Progression...) :
This study addresses whether targeting
Heat shock protein 90 (HSP90) regulation of
androgen receptor (AR) can inhibit prostate cancer progression to castration resistance