Yu et al., Mol Pharmacol 2001
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Interestingly, resveratrol had little effect on the induction of AP-1 reporter gene by active Raf-1 , MEKK1, or MKK6, suggesting that it inhibited MAPK pathways by targeting the signaling molecules upstream of Raf-1 or MEKK1
Lim et al., American journal of translational research 2009
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Ras-Raf1-ERK1/2 dependent AP-1 activation positively regulates MUC5AC mucin induction by S. pneumoniae, whereas MEKK3-JNK1/2 dependent AP-1 activation negatively regulates it
Li et al., EMBO J 1995
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The same results were obtained in vivo using transfection assays ; 14-3-3 enhanced both c-Raf-1- and Raf-1 kinase domain stimulated expression of AP-1- and NF-kappa B-dependent reporter genes and accelerated Raf-1 kinase domain triggered differentiation of PC12 cells