◀ Back to CCND1
CCND1 — CDK6
Pathways - manually collected, often from reviews:
-
BioCarta cell cycle: g1/s check point:
CYCLIN D1/CDK4/CDK6 complex (CCND1-CDK4-CDK6)
→
SKP2
(protein ubiquitination, collaborate)
-
BioCarta influence of ras and rho proteins on g1 to s transition:
CYCLIN D1/CDK4/CDK6 complex (CCND1-CDK4-CDK6)
→
RB/E2F-1 complex (E2F1-RB1)
(modification, activates)
-
BioCarta influence of ras and rho proteins on g1 to s transition:
CYCLIN D1/CDK4/CDK6 complex (CCND1-CDK4-CDK6)
→
E2F-1 (E2F1)
(modification, activates)
-
BioCarta influence of ras and rho proteins on g1 to s transition:
CYCLIN D1/CDK4/CDK6 complex (CCND1-CDK4-CDK6)
→
RB (RB1)
(modification, activates)
-
BioCarta cell cycle: g1/s check point:
RB/HDAC/ABL/E2F-1/DP-1 complex (E2F1-RB1-TFDP1-ABL1-HDAC1)
→
CYCLIN D1/CDK4/CDK6 complex (CCND1-CDK4-CDK6)
(modification, collaborate)
-
BioCarta cell cycle: g1/s check point:
CYCLIN D1/CDK4/CDK6 complex (CCND1-CDK4-CDK6)
→
E2F-1/DP-1 complex (TFDP1-E2F1)
(modification, activates)
-
BioCarta influence of ras and rho proteins on g1 to s transition:
CYCLIN D1/CDK4/CDK6 complex (CCND1-CDK4-CDK6)
→
CYCLIN D1 (CCND1)
(modification, collaborate)
-
BioCarta influence of ras and rho proteins on g1 to s transition:
CYCLIN D1/CDK4/CDK6 complex (CCND1-CDK4-CDK6)
→
CDK6
(modification, collaborate)
-
BioCarta influence of ras and rho proteins on g1 to s transition:
CYCLIN D1/CDK4/CDK6 complex (CCND1-CDK4-CDK6)
→
CDK4
(modification, collaborate)
-
BioCarta influence of ras and rho proteins on g1 to s transition:
CYCLIN D1 (CCND1)
→
CDK6
(modification, collaborate)
-
KEGG Cell cycle:
CDKN1B/CDKN1C
→
Complex of CCND1-CCND2-CCND3-CDK4-CDK6
(protein-protein, inhibition)
-
KEGG Cell cycle:
CDKN1A
→
Complex of CCND1-CCND2-CCND3-CDK4-CDK6
(protein-protein, inhibition)
-
KEGG Cell cycle:
PCNA
→
Complex of CCND1-CCND2-CCND3-CDK4-CDK6
(protein-protein, inhibition)
-
KEGG Cell cycle:
CDKN2B
→
Complex of CCND1-CCND2-CCND3-CDK4-CDK6
(protein-protein, inhibition)
-
KEGG Cell cycle:
Complex of CCND1-CCND2-CCND3-CDK4-CDK6
→
RBL1/RBL2
(protein-protein, inhibition)
-
KEGG Cell cycle:
Complex of CCND1-CCND2-CCND3-CDK4-CDK6
→
RB1
(protein-protein, inhibition)
-
KEGG Cell cycle:
CDKN2A
→
Complex of CCND1-CCND2-CCND3-CDK4-CDK6
(protein-protein, inhibition)
-
KEGG Cell cycle:
CDKN2C
→
Complex of CCND1-CCND2-CCND3-CDK4-CDK6
(protein-protein, inhibition)
-
KEGG Cell cycle:
CDKN2D
→
Complex of CCND1-CCND2-CCND3-CDK4-CDK6
(protein-protein, inhibition)
-
KEGG p53 signaling pathway:
CDKN1A
→
Complex of CCND1-CCND2-CCND3-CDK4-CDK6
(protein-protein, inhibition)
-
KEGG Pathways in cancer:
CDKN2B
→
Complex of CCND1-CDK4-CDK6
(protein-protein, inhibition)
-
KEGG Pathways in cancer:
Complex of CCND1-CDK4-CDK6
→
RB1
(protein-protein, activation)
-
KEGG Pathways in cancer:
CDKN2A
→
Complex of CCND1-CDK4-CDK6
(protein-protein, missing interaction)
-
KEGG Pathways in cancer:
CDKN1A
→
Complex of CCND1-CDK4-CDK6
(protein-protein, inhibition)
-
KEGG Pancreatic cancer:
CDK4/CDK6
→
CCND1
(protein-protein, binding/association)
-
KEGG Pancreatic cancer:
Complex of CCND1-CDK4-CDK6
→
RB1
(protein-protein, activation)
-
KEGG Glioma:
Complex of CCND1-CDK4-CDK6
→
RB1
(protein-protein, activation)
-
KEGG Glioma:
Complex of CCND1-CDK4-CDK6
→
RB1
(protein-protein, activation)
-
KEGG Glioma:
CDKN2A
→
Complex of CCND1-CDK4-CDK6
(protein-protein, missing interaction)
-
KEGG Glioma:
CDKN1A
→
Complex of CCND1-CDK4-CDK6
(protein-protein, inhibition)
-
KEGG Melanoma:
Complex of CCND1-CDK4-CDK6
→
RB1
(protein-protein, activation)
-
KEGG Melanoma:
CDKN1A
→
Complex of CCND1-CDK4-CDK6
(protein-protein, inhibition)
-
KEGG Melanoma:
CDKN2A
→
Complex of CCND1-CDK4-CDK6
(protein-protein, missing interaction)
-
KEGG Chronic myeloid leukemia:
Complex of CCND1-CDK4-CDK6
→
RB1
(protein-protein, activation)
-
KEGG Chronic myeloid leukemia:
CDKN1A
→
Complex of CCND1-CDK4-CDK6
(protein-protein, inhibition)
-
KEGG Chronic myeloid leukemia:
CDKN2A
→
Complex of CCND1-CDK4-CDK6
(protein-protein, missing interaction)
-
KEGG Small cell lung cancer:
Complex of CCND1-CDK4-CDK6
→
RB1
(protein-protein, activation)
-
KEGG Small cell lung cancer:
Complex of MAX-MYC
→
Complex of CCND1-CDK4-CDK6
(gene expression, expression)
-
KEGG Small cell lung cancer:
CDKN2B
→
Complex of CCND1-CDK4-CDK6
(protein-protein, inhibition)
-
KEGG Non-small cell lung cancer:
Complex of CCND1-CDK4-CDK6
→
RB1
(protein-protein, activation)
-
KEGG Non-small cell lung cancer:
CDKN2A
→
Complex of CCND1-CDK4-CDK6
(protein-protein, missing interaction)
-
NCI Pathway Database Regulation of retinoblastoma protein:
RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1)
→
CDK4-6/Cyclin D/p16INK4a complex (CDK6_CDK4-CCND3_CCND2_CCND1-CDKN2A)
(modification, collaborate)
Zhang et al., Cell 2000, Rubin et al., Cell 2005, Kato et al., Genes Dev 1993, Fåhraeus et al., Curr Biol 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1)
→
CDK4-6/Cyclin D complex (CDK6_CDK4-CCND3_CCND2_CCND1)
(modification, collaborate)
Zhang et al., Cell 2000, Rubin et al., Cell 2005, Kato et al., Genes Dev 1993, Fåhraeus et al., Curr Biol 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
CDK4-6/Cyclin D/p16INK4a complex (CDK6_CDK4-CCND3_CCND2_CCND1-CDKN2A)
→
HDAC1 (HDAC1)
(modification, inhibits)
Zhang et al., Cell 2000, Rubin et al., Cell 2005, Kato et al., Genes Dev 1993, Fåhraeus et al., Curr Biol 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
CDK4-6/Cyclin D/p16INK4a complex (CDK6_CDK4-CCND3_CCND2_CCND1-CDKN2A)
→
CDK4-6/Cyclin D complex (CDK6_CDK4-CCND3_CCND2_CCND1)
(modification, inhibits)
Zhang et al., Cell 2000, Rubin et al., Cell 2005, Kato et al., Genes Dev 1993, Fåhraeus et al., Curr Biol 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
RB1/E2F1-3/DP/SUV39H1 complex (RB1-SUV39H1-E2F3_E2F2_E2F1-TFDP1)
→
CDK4-6/Cyclin D complex (CDK6_CDK4-CCND3_CCND2_CCND1)
(modification, collaborate)
Vandel et al., Mol Cell Biol 2001
Evidence: assay
-
NCI Pathway Database C-MYB transcription factor network:
p21CIP1 (CDKN1A)
→
CDK6/Cyclin D1 complex (CDK6-CCND1)
(modification, activates)
Lei et al., Blood 2005*
-
NCI Pathway Database C-MYB transcription factor network:
Myb (MYB)
→
CDK6/Cyclin D1/Myb complex (CDK6-CCND1-MYB)
(modification, collaborate)
Lei et al., Blood 2005*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database C-MYB transcription factor network:
Myb (MYB)
→
CDK6/Cyclin D1 complex (CDK6-CCND1)
(modification, collaborate)
Lei et al., Blood 2005*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database C-MYB transcription factor network:
CDK6/Cyclin D1/Myb complex (CDK6-CCND1-MYB)
→
CDK6/Cyclin D1 complex (CDK6-CCND1)
(modification, collaborate)
Lei et al., Blood 2005*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database C-MYB transcription factor network:
p16INK4a (CDKN2A)
→
CDK6/Cyclin D1 complex (CDK6-CCND1)
(modification, activates)
Lei et al., Blood 2005*
-
NCI Pathway Database Coregulation of Androgen receptor activity:
T-DHT/AR/CyclinD1 complex (AR-CCND1)
→
T-DHT/AR/CDK6 complex (AR-CDK6)
(transcription, inhibits)
Knudsen et al., Cancer Res 1999*, Lim et al., Proc Natl Acad Sci U S A 2005*
Evidence: mutant phenotype, reporter gene
-
NCI Pathway Database Regulation of retinoblastoma protein:
p16INK4a (CDKN2A)
→
CDK4-6/Cyclin D/p16INK4a complex (CDK6_CDK4-CCND3_CCND2_CCND1-CDKN2A)
(modification, collaborate)
Fåhraeus et al., Curr Biol 1996
Evidence: physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
p16INK4a (CDKN2A)
→
CDK4-6/Cyclin D complex (CDK6_CDK4-CCND3_CCND2_CCND1)
(modification, collaborate)
Fåhraeus et al., Curr Biol 1996
Evidence: physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
CDK4-6/Cyclin D/p16INK4a complex (CDK6_CDK4-CCND3_CCND2_CCND1-CDKN2A)
→
CDK4-6/Cyclin D complex (CDK6_CDK4-CCND3_CCND2_CCND1)
(modification, collaborate)
Fåhraeus et al., Curr Biol 1996
Evidence: physical interaction
-
WikiPathways Retinoblastoma (RB) in Cancer:
Complex of CDK6-CCND1
→
RB1
(mim-inhibition)
-
WikiPathways Signaling Pathways in Glioblastoma:
MAPK1/MAPK3
→
Complex of CCND1-CCND2-CDK6
(mim-stimulation)
-
WikiPathways Signaling Pathways in Glioblastoma:
CDKN2A/CDKN2C/CDKN2B
→
Complex of CCND1-CCND2-CDK6
(mim-inhibition)
-
WikiPathways Signaling Pathways in Glioblastoma:
CDKN1A
→
Complex of CCND1-CCND2-CDK6
(mim-inhibition)
-
WikiPathways Signaling Pathways in Glioblastoma:
Complex of CCND1-CCND2-CDK6
→
RB1
(mim-inhibition)
-
WikiPathways miRNA Regulation of DNA Damage Response:
Complex of CDK4-CCND1-CDK6-CCND2-CCND3-CDK5
→
Complex of CDK2-CCNE2-CCNE1
(inhibition)
-
WikiPathways miRNA Regulation of DNA Damage Response:
CDC25A
→
Complex of CDK4-CCND1-CDK6-CCND2-CCND3-CDK5
(activation)
-
WikiPathways DNA Damage Response:
Complex of CDK4-CCND1-CDK6-CCND2-CCND3-CDK5
→
Complex of CDK2-CCNE2-CCNE1
(inhibition)
-
WikiPathways DNA Damage Response:
CDC25A
→
Complex of CDK4-CCND1-CDK6-CCND2-CCND3-CDK5
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind_translation Interaction:
CDK6
—
CCND1
(coimmunoprecipitation)
Dupont et al., J Biol Chem 2003*
-
IRef Bind_translation Interaction:
CDK6
—
CCND1
(array technology)
Ramachandran et al., Science 2004
-
IRef Bind_translation Interaction:
CDK6
—
CCND1
(coimmunoprecipitation)
Laman et al., EMBO J 2005
-
IRef Biogrid Interaction:
CDK6
—
CCND1
(physical association, affinity chromatography technology)
Lin et al., Oncogene 2001*
-
IRef Biogrid Interaction:
CDK6
—
CCND1
(physical association, affinity chromatography technology)
Sweeney et al., Oncogene 1997*
-
IRef Biogrid Interaction:
CDK6
—
CCND1
(colocalization, biochemical)
Ruas et al., Mol Cell Biol 2007*
-
IRef Biogrid Interaction:
CDK6
—
CCND1
(physical association, affinity chromatography technology)
Shu et al., Proc Natl Acad Sci U S A 2007*
-
IRef Biogrid Interaction:
CDK6
—
CCND1
(direct interaction, pull down)
Sugimoto et al., Genes Dev 1999*
-
IRef Biogrid Interaction:
CDK6
—
CCND1
(direct interaction, pull down)
Ramachandran et al., Science 2004
-
MIPS CORUM CyclinD1-CDK4-CDK6 complex:
CyclinD1-CDK4-CDK6 complex complex (CCND1-CDK4-CDK6)
Wang et al., Cell Growth Differ 1996*
-
MIPS CORUM CCND1-CDK6 complex:
CCND1-CDK6 complex complex (CCND1-CDK6)
Lundberg et al., Mol Cell Biol 1998*
-
IRef Corum Interaction:
CDK6
—
CCND1
(association, coimmunoprecipitation)
Lundberg et al., Mol Cell Biol 1998*
-
IRef Corum Interaction:
Complex of CDK6-CCND1-CDK4
(association, anti tag coimmunoprecipitation)
Wang et al., Cell Growth Differ 1996*
-
IRef Hprd Interaction:
CDK6
—
CCND1
(in vitro)
Kaldis et al., Mol Biol Cell 2001*, Ramachandran et al., Science 2004, Shu et al., Proc Natl Acad Sci U S A 2007*, Ray et al., Mol Cell Biol 2009*
-
IRef Hprd Interaction:
CDK6
—
CCND1
(in vivo)
Kaldis et al., Mol Biol Cell 2001*, Ramachandran et al., Science 2004, Shu et al., Proc Natl Acad Sci U S A 2007*, Ray et al., Mol Cell Biol 2009*
-
IRef Hprd Interaction:
Complex of 17 proteins
(in vivo)
Farkas et al., J Biol Chem 2002*
-
IRef Hprd Interaction:
Complex of 17 proteins
(in vivo)
Ezhevsky et al., Proc Natl Acad Sci U S A 1997*
-
IRef Intact Interaction:
CDK6
—
CCND1
(direct interaction, inferred by curator)
Hermjakob et al., Nucleic Acids Res 2004
-
IRef Intact Interaction:
CDK6
—
CCND1
(direct interaction, protein array)
Ramachandran et al., Science 2004
-
IRef Intact Interaction:
Complex of CCND3-CDK6-CCND1
(association, anti bait coimmunoprecipitation)
Shu et al., Proc Natl Acad Sci U S A 2007*
-
IRef Ophid Interaction:
CDK6
—
CCND1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Chang et al., Int J Oncol 2000
(Neoplasms, Experimental) :
Inhibition of
cyclin D1 expression or
induction of
cyclin dependent kinase inhibitor p21WAF1 expression was found in mimosine treated lung cancer cells
Osborne et al., Br J Dermatol 2002
(Breast Neoplasms...) :
1,25 ( OH ) 2D3 has a major inhibitory effect on the G1/S checkpoint of the cell cycle by upregulating the
cyclin dependent kinase inhibitors p27 and p21, and by
inhibiting cyclin D1
Lim et al., Proc Natl Acad Sci U S A 2005
(Prostatic Neoplasms) :
Cyclin dependent kinase 6 (CDK6) binds to and is
activated by
cyclin D1 and thereby enhances the transition of cells through the G1 phase of the cell cycle
Brennan et al., J Med Food 2012
(Adrenocortical Carcinoma) :
BME treatment enhanced cellular tumor antigen p53,
cyclin dependent kinase inhibitor 1A ( also called p21 ), and cyclic AMP dependent transcription factor-3 levels and
inhibited G1/S-specific cyclin D1 , D2, and D3, and mitogen activated protein kinase 8 ( also called Janus kinase ) expression, suggesting an additional mechanism involving cell cycle regulation and cell survival
Kang et al., Apoptosis 2012
:
Cell cycle analysis indicated thioridazine induced the down-regulation of
cyclin D1 , cyclin A and CDK4, and the induction of p21 and p27, a
cyclin dependent kinase inhibitor
Sweeney et al., Oncogene 1997
(Breast Neoplasms) :
In contrast, Cdk4 and
Cdk6 were predominantly
responsible for
cyclin D1-associated kinase activity as previously reported