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Cherukuri et al., Cancer Biol Ther 2005
(Colorectal Neoplasms) :
These results suggest that Se-Met regulates COX-2 at transcriptional level by modulating the activity of NF-kappaB transcription factor
Shida et al., World J Gastroenterol 2005
(Colonic Neoplasms) :
Lysophosphatidic acid transactivates both c-Met and epidermal growth factor receptor, and induces cyclooxygenase-2 expression in human colon cancer LoVo cells
Tuynman et al., Cancer Res 2008
(Colonic Neoplasms) :
Cyclooxygenase-2 inhibition inhibits c-Met kinase activity and Wnt activity in colon cancer
Moore et al., Carcinogenesis 2009
(Adenoma...) :
Notably, inhibition of Met with the small molecule inhibitor SU11274 reduced COX-2 expression and increased 15-PGDH expression in high Met expressing cells