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CYR61 — FOXO3
Text-mined interactions from Literome
Lee et al., Circ Res 2007
(Atherosclerosis...) :
We hypothesized that the forkhead transcription factor
FOXO3a may
regulate CYR61 expression in VSMCs and investigated the CYR61 modulating effect of FOXO3a in the process of vascular response to vasoactive signals and vascular injury ... To evaluate the
effect of
FOXO3a on
CYR61 expression, rat VSMCs were infected with adenoviral vectors expressing constitutively active FOXO3a ( Ad-TM-FOXO3a ) ... Luciferase assay with the deletion constructs of the forkhead factor binding motif in CYR61 promoter region, which resulted in a significant decrease in luciferase expression compared with the intact construct, and chromatin immunoprecipitation analysis confirmed transcriptional
regulation of
CYR61 by
FOXO3a
Kok et al., Arthritis Rheum 2013
(Arthritis, Experimental...) :
To examine the
role of sirtuin-1
(SIRT-1)/FoxO3a in the expression of
cysteine-rich protein 61 (CYR-61) in rheumatoid arthritis synovial fibroblasts ( RASFs ) and the influence of simvastatin on this pathway, and to determine the relationship between disease progression and FoxO3a/CYR-61 signaling in synovial fibroblasts in vivo using a rat model of collagen induced arthritis ( CIA )
Lin et al., J Endod 2013
:
Forced expression of
FoxO3a reduced TNF-a stimulated
Cyr61 synthesis